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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lrp5tm1.1Vari
targeted mutation 1.1, van Andel Research Institute
MGI:5299215
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lrp5tm1.1Vari/Lrp5tm1.1Vari involves: 129S1/Sv MGI:5299316
cn2
Lrp5tm1.1Vari/Lrp5tm1.2Vari
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ MGI:5299319
cn3
Lrp5tm1.1Vari/Lrp5tm1.1Vari
Lrp6tm1.1Vari/Lrp6tm1.1Vari
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ MGI:5299323


Genotype
MGI:5299316
hm1
Allelic
Composition
Lrp5tm1.1Vari/Lrp5tm1.1Vari
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1.1Vari mutation (1 available); any Lrp5 mutation (82 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice develop and reproduce normally




Genotype
MGI:5299319
cn2
Allelic
Composition
Lrp5tm1.1Vari/Lrp5tm1.2Vari
Twist2tm1(cre)Dor/Twist2+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1.1Vari mutation (1 available); any Lrp5 mutation (82 available)
Lrp5tm1.2Vari mutation (0 available); any Lrp5 mutation (82 available)
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
N
• mice exhibit relatively normal skeleton




Genotype
MGI:5299323
cn3
Allelic
Composition
Lrp5tm1.1Vari/Lrp5tm1.1Vari
Lrp6tm1.1Vari/Lrp6tm1.1Vari
Twist2tm1(cre)Dor/Twist2+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1.1Vari mutation (1 available); any Lrp5 mutation (82 available)
Lrp6tm1.1Vari mutation (1 available); any Lrp6 mutation (95 available)
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die shortly after birth

skeleton
• all skeletal elements are shortened
• mice exhibit partial bone collar
• mice exhibit extra cartilage elements (typically 4) in the zeugopod and in some autopods
• at the diaphysis
• profound defect in ossification of the craniofacial, the rest of the axial, and the appendicular skeleton
• partial ossification of the scapula and ileum
• however, some ossification of zeugopod elements and other skeletal elements is observed

growth/size/body

limbs/digits/tail

craniofacial





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory