Analysis Tools|
Allele Symbol Allele Name Allele ID |
Lrp6tm1.1Vari targeted mutation 1.1, van Andel Research Institute MGI:5299216 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit relatively normal skeleton
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• at E17.5, mice exhibit a slight delay in ossification of the skull compared with control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit relatively normal skeleton
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• at E17.5, mice exhibit a slight delay in ossification of the skull compared with control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die shortly after birth
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• all skeletal elements are shortened
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• mice exhibit partial bone collar
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• absent
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• mice exhibit extra cartilage elements (typically 4) in the zeugopod and in some autopods
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• at the diaphysis
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• profound defect in ossification of the craniofacial, the rest of the axial, and the appendicular skeleton
• partial ossification of the scapula and ileum
• however, some ossification of zeugopod elements and other skeletal elements is observed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die shortly after birth
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• all skeletal elements are shortened
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• mice exhibit partial bone collar
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• mature osteoblasts fail to form
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• absent
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• mice exhibit extra cartilage elements (typically 4) in the zeugopod and in some autopods
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• at the diaphysis and surrounding the marrow cavity
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• mice lack joints at multiple locations including the knees
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• at E14.5, mice exhibit a delay in chondrocyte hypertrophy
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• profound defect in ossification of the craniofacial, the rest of the axial, and the appendicular skeleton
• partial ossification of the scapula and ileum
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• except for the scapula and ileum
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• mature osteoblasts fail to form
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• mice exhibit an additional element bridging the zeugopod and stylopod
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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