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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrp5tm1.2Vari
targeted mutation 1.2, van Andel Research Institute
MGI:5299217
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lrp5tm1.2Vari/Lrp5tm1.2Vari involves: 129S1/Sv MGI:5299318
cn2
 		Lrp5tm1.1Vari/Lrp5tm1.2Vari
Twist2tm1(cre)Dor/Twist2+ 		involves: 129S1/Sv * 129X1/SvJ MGI:5299319
cn3
 		Lrp5tm1.2Vari/Lrp5tm1.2Vari
Lrp6tm1.1Vari/Lrp6tm1.1Vari
Twist2tm1(cre)Dor/Twist2+ 		involves: 129S1/Sv * 129X1/SvJ MGI:5299324


Genotype
MGI:5299318
hm1
Allelic
Composition		 Lrp5tm1.2Vari/Lrp5tm1.2Vari
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1.2Vari mutation (0 available); any Lrp5 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:178499 )
N
• mice exhibit relatively normal skeleton
decreased bone mass ( J:178499 )
• postnatally




Genotype
MGI:5299319
cn2
Allelic
Composition		 Lrp5tm1.1Vari/Lrp5tm1.2Vari
Twist2tm1(cre)Dor/Twist2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1.1Vari mutation (1 available); any Lrp5 mutation (82 available)
Lrp5tm1.2Vari mutation (0 available); any Lrp5 mutation (82 available)
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:178499 )
N
• mice exhibit relatively normal skeleton




Genotype
MGI:5299324
cn3
Allelic
Composition		 Lrp5tm1.2Vari/Lrp5tm1.2Vari
Lrp6tm1.1Vari/Lrp6tm1.1Vari
Twist2tm1(cre)Dor/Twist2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1.2Vari mutation (0 available); any Lrp5 mutation (82 available)
Lrp6tm1.1Vari mutation (1 available); any Lrp6 mutation (95 available)
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:178499 )
• mice die shortly after birth

skeleton
abnormal skeleton morphology ( J:178499 )
• all skeletal elements are shortened
abnormal bone structure ( J:178499 )
• mice exhibit partial bone collar
abnormal osteoblast differentiation ( J:178499 )
• mature osteoblasts fail to form
abnormal cartilage morphology ( J:178499 )
• mice exhibit extra cartilage elements (typically 4) in the zeugopod and in some autopods
ectopic cartilage ( J:178499 )
• at the diaphysis and surrounding the marrow cavity
abnormal joint morphology ( J:178499 )
• mice lack joints at multiple locations including the knees
decreased width of hypertrophic chondrocyte zone ( J:178499 )
• at E14.5, mice exhibit a delay in chondrocyte hypertrophy
abnormal bone ossification ( J:178499 )
• profound defect in ossification of the craniofacial, the rest of the axial, and the appendicular skeleton
• partial ossification of the scapula and ileum
failure of bone ossification ( J:178499 )
• except for the scapula and ileum

growth/size/body
decreased body size ( J:178499 )

cellular
abnormal osteoblast differentiation ( J:178499 )
• mature osteoblasts fail to form

limbs/digits/tail
abnormal limb morphology ( J:178499 )
• mice exhibit an additional element bridging the zeugopod and stylopod

craniofacial




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory