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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrp6tm1.2Vari
targeted mutation 1.2, van Andel Research Institute
MGI:5299218
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lrp6tm1.2Vari/Lrp6tm1.2Vari involves: 129S1/Sv MGI:5299322
cn2
 		Lrp6tm1.1Vari/Lrp6tm1.2Vari
Twist2tm1(cre)Dor/Twist2+ 		involves: 129S1/Sv * 129X1/SvJ MGI:5299321


Genotype
MGI:5299322
hm1
Allelic
Composition		 Lrp6tm1.2Vari/Lrp6tm1.2Vari
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6tm1.2Vari mutation (0 available); any Lrp6 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:178499 )
• mice die at birth with multiple defects observed in Lrp6Gt(Ex187)Byg




Genotype
MGI:5299321
cn2
Allelic
Composition		 Lrp6tm1.1Vari/Lrp6tm1.2Vari
Twist2tm1(cre)Dor/Twist2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6tm1.1Vari mutation (1 available); any Lrp6 mutation (95 available)
Lrp6tm1.2Vari mutation (0 available); any Lrp6 mutation (95 available)
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:178499 )
N
• mice exhibit relatively normal skeleton
delayed bone ossification ( J:178499 )
• at E17.5, mice exhibit a slight delay in ossification of the skull compared with control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory