Phenotypes associated with this allele

• Allele Symbol: Tdo2^tm1Tnak
• Allele Name: targeted mutation 1, Toshikazu Nakamura
• Allele ID: MGI:5299329
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tdo2^tm1Tnak/Tdo2^tm1Tnak	B6.129-Tdo2^tm1Tnak	MGI:5299331

Genotype
MGI:5299331

hm1

• Allelic Composition: Tdo2^tm1Tnak/Tdo2^tm1Tnak
• Genetic Background: B6.129-Tdo2^tm1Tnak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:177903 )

• at 13 weeks of age, mice exhibit accelerated adult neurogenesis in the granule cell layer of the olfactory bulb compared with wild-type mice

abnormal neuronal precursor proliferation ( J:177903 )

• increased at 13 weeks of age in the dentate gyrus and subventricular zone

abnormal olfactory bulb development ( J:177903 )

• at 13 weeks of age, mice exhibit accelerated adult neurogenesis in the granule cell layer of the olfactory bulb compared with wild-type mice

small lateral ventricles ( J:177903 )

• decreased size

homeostasis/metabolism

abnormal amino acid level ( J:177903 )

• tryptophan concentrations in the hippocampus and midbrain are increased more than 20-fold compared to in wild-type mice

abnormal circulating amino acid level ( J:177903 )

• tryptophan and tryptophan metabolite kynurenine plasma levels are increased 9.3-fold and 2-fold, respectively, compared to in wild-type mice

increased circulating methionine level ( J:177903 )

• methionine plasma levels are increased 1.3-fold compared with wild-type mice

increased circulating threonine level ( J:177903 )

• threonine plasma levels are increased 1.3-fold compared with wild-type mice

increased serotonin level ( J:177903 )

• 2-fold in the midbrain and hippocampus, 5-fold higher 5-HT metabolite 5-HIAA

behavior/neurological

behavior/neurological phenotype ( J:177903 )

N • mice exhibit normal total locomotion in an open field test

decreased anxiety-related response ( J:177903 )

• in an elevated plus maze test, mice spend more time in the open arms compared with wild-type mice

• in an open field test, mice spend more time in the center and increased locomotion in the center area compared with wild-type mice

cellular

abnormal neuron differentiation ( J:177903 )

• at 13 weeks of age, mice exhibit accelerated adult neurogenesis in the granule cell layer of the olfactory bulb compared with wild-type mice

abnormal neuronal precursor proliferation ( J:177903 )

• increased at 13 weeks of age in the dentate gyrus and subventricular zone