All Phenotypes Creb1<tm1.1Berd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Creb1^tm1.1Berd
targeted mutation 1.1, Rebecca Berdeaux
MGI:5299333

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Creb1^tm1.1Berd/Creb1^tm1.1Berd	B6NHsd.129S4-Creb1^tm1.1Berd	MGI:5299345
cx2	Creb1^tm1.1Berd/Creb1^tm1.1Berd Dmd^mdx/Y	B.Cg-Creb1^tm1.1Berd Dmd^mdx	MGI:5299346

Allelic Composition	Creb1^tm1.1Berd/Creb1^tm1.1Berd
Genetic Background	B6NHsd.129S4-Creb1^tm1.1Berd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Creb1^tm1.1Berd mutation (0 available); any Creb1 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased myoblast proliferation ( J:177923 )

• myotube density is slightly increased due to increased myoblast proliferation

• however, myoblasts differentiate normally into myotubes

muscle

muscle phenotype ( J:177923 )

N	• mice exhibit normal muscle structure

increased myoblast proliferation ( J:177923 )

• myotube density is slightly increased due to increased myoblast proliferation

• however, myoblasts differentiate normally into myotubes

abnormal myotube morphology ( J:177923 )

• myotube density is slightly increased due to increased myoblast proliferation

enhanced skeletal muscle regeneration ( J:177923 )

• regenerating muscle exhibits increased cell proliferation compared to in wild-type mice

Allelic Composition	Creb1^tm1.1Berd/Creb1^tm1.1Berd Dmd^mdx/Y
Genetic Background	B.Cg-Creb1^tm1.1Berd Dmd^mdx

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Creb1^tm1.1Berd mutation (0 available); any Creb1 mutation (61 available)
Dmd^mdx mutation (31 available); any Dmd mutation (154 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

skeletal muscle degeneration ( J:177923 )

• muscle degeneration proceeds as in Dmd^mdx mice

enhanced skeletal muscle regeneration ( J:177923 )

• muscle regeneration is increased compared to in Dmd^mdx mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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