All Phenotypes Scrib<tm1.1Phum> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Scrib^tm1.1Phum
targeted mutation 1.1, Patrick O Humbert
MGI:5299425

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kras^tm4Tyj/Kras⁺ Scrib^tm1.1Phum/Scrib^tm1.1Phum	involves: 129S4/SvJae	MGI:5638045
cn2	Kras^tm4Tyj/Kras⁺ Scrib^tm1.1Phum/Scrib⁺	involves: 129S4/SvJae	MGI:5638047
cn3	Kras^tm4Tyj/Kras⁺ Scrib^tm1.1Phum/Scrib^tm1.1Phum Tg(Pbsn-cre)20Fwan/0	involves: 129S4/SvJae * FVB/NCrl	MGI:5300204
cn4	Kras^tm4Tyj/Kras⁺ Scrib^tm1.1Phum/Scrib⁺ Tg(Pbsn-cre)20Fwan/0	involves: 129S4/SvJae * FVB/NCrl	MGI:5300205
cn5	Scrib^tm1.1Phum/Scrib^tm1.1Phum Tg(Pbsn-cre)20Fwan/0	involves: FVB/NCrl	MGI:5300202

Allelic Composition	Kras^tm4Tyj/Kras⁺ Scrib^tm1.1Phum/Scrib^tm1.1Phum
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Scrib^tm1.1Phum mutation (0 available); any Scrib mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased lung tumor incidence ( J:216266 )

• 100% of mice develop lung lesions at 6 weeks post intranasal adenoviral cre (AdCre) administration, ranging from grades 1 to 3

• mice show accelerated lung tumorigenesis, with more advanced and higher-grade tumors post intranasal AdCre administration compared to single Kras heterozygotes

• a 2.9-fold increase in tumor burden compared to single Kras heterozygotes at 12 weeks post intranasal AdCre administration

• lung tumors from intranasally AdCre treated mice show enhanced stromal reactivity and inflammation

respiratory system

increased lung tumor incidence ( J:216266 )

• 100% of mice develop lung lesions at 6 weeks post intranasal adenoviral cre (AdCre) administration, ranging from grades 1 to 3

• mice show accelerated lung tumorigenesis, with more advanced and higher-grade tumors post intranasal AdCre administration compared to single Kras heterozygotes

• a 2.9-fold increase in tumor burden compared to single Kras heterozygotes at 12 weeks post intranasal AdCre administration

• lung tumors from intranasally AdCre treated mice show enhanced stromal reactivity and inflammation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:216266

Allelic Composition	Kras^tm4Tyj/Kras⁺ Scrib^tm1.1Phum/Scrib⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased lung tumor incidence ( J:216266 )

• 83% of mice develop tumors ranging from grades 1 to 3 at 6 weeks post intranasal adenoviral cre (AdCre) administration

respiratory system

increased lung tumor incidence ( J:216266 )

• 83% of mice develop tumors ranging from grades 1 to 3 at 6 weeks post intranasal adenoviral cre (AdCre) administration

lung epithelium hyperplasia ( J:216266 )

• 100% of mice show epithelial hyperplasia at 6 weeks post intranasal AdCre administration

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:216266

Allelic Composition	Kras^tm4Tyj/Kras⁺ Scrib^tm1.1Phum/Scrib^tm1.1Phum Tg(Pbsn-cre)20Fwan/0
Genetic Background	involves: 129S4/SvJae * FVB/NCrl

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:178461 )

• 3 of 10 mice exhibit signs of illness and were sacrificed prior to 400 days

reproductive system

prostate gland hyperplasia ( J:178461 )

increased prostate gland adenocarcinoma incidence ( J:178461 )

• well-differentiated adenocarcinomas in 20% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• high-grade in 33% of mice

abnormal prostate gland physiology ( J:178461 )

• increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• high-grade in 33% of mice

increased carcinoma incidence ( J:178461 )

• 3 of 15 mice develop poorly differentiated invasive carcinoma

increased prostate gland adenocarcinoma incidence ( J:178461 )

• well-differentiated adenocarcinomas in 20% of mice

digestive/alimentary system

abnormal intestine morphology ( J:178461 )

• focal intestinal metaplasia

endocrine/exocrine glands

prostate gland hyperplasia ( J:178461 )

increased prostate gland adenocarcinoma incidence ( J:178461 )

• well-differentiated adenocarcinomas in 20% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• high-grade in 33% of mice

abnormal prostate gland physiology ( J:178461 )

• increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:178461

Allelic Composition	Kras^tm4Tyj/Kras⁺ Scrib^tm1.1Phum/Scrib⁺ Tg(Pbsn-cre)20Fwan/0
Genetic Background	involves: 129S4/SvJae * FVB/NCrl

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

increased prostate gland adenocarcinoma incidence ( J:178461 )

• well-differentiated adenocarcinomas in 13% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• high-grade in 20% of mice

abnormal prostate gland physiology ( J:178461 )

• increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice

neoplasm

increased prostate gland adenocarcinoma incidence ( J:178461 )

• well-differentiated adenocarcinomas in 13% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• high-grade in 20% of mice

digestive/alimentary system

abnormal intestine morphology ( J:178461 )

• focal intestinal metaplasia

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:178461 )

• well-differentiated adenocarcinomas in 13% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• high-grade in 20% of mice

abnormal prostate gland physiology ( J:178461 )

• increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice

Allelic Composition	Scrib^tm1.1Phum/Scrib^tm1.1Phum Tg(Pbsn-cre)20Fwan/0
Genetic Background	involves: FVB/NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scrib^tm1.1Phum mutation (0 available); any Scrib mutation (54 available)
Tg(Pbsn-cre)20Fwan mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

prostate gland hyperplasia ( J:178461 )

• 88% at 100 days, 75% at 200 days, and 90% at 400 days

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• low-grade

abnormal prostate gland physiology ( J:178461 )

• increase in cell proliferation compared with control

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• low-grade

endocrine/exocrine glands

prostate gland hyperplasia ( J:178461 )

• 88% at 100 days, 75% at 200 days, and 90% at 400 days

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• low-grade

abnormal prostate gland physiology ( J:178461 )

• increase in cell proliferation compared with control

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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