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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Scribtm1.2Phum
targeted mutation 1.2, Patrick O Humbert
MGI:5299427
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Scribtm1.2Phum/Scribtm1.2Phum involves: FVB/N MGI:5300206
ht2
 		Scribtm1.2Phum/Scrib+ involves: FVB/N MGI:5300207


Genotype
MGI:5300206
hm1
Allelic
Composition		 Scribtm1.2Phum/Scribtm1.2Phum
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scribtm1.2Phum mutation (0 available); any Scrib mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Craniorachischisis in Scribtm1.2Phum/Scribtm1.2Phum mice

mortality/aging

reproductive system
abnormal gonad rudiment morphology ( J:178461 )
• gonads are short and misshapen

nervous system

vision/eye

limbs/digits/tail

growth/size/body
herniated abdominal wall ( J:178461 )
• in 14 of 26 mice

embryo




Genotype
MGI:5300207
ht2
Allelic
Composition		 Scribtm1.2Phum/Scrib+
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scribtm1.2Phum mutation (0 available); any Scrib mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Prostate hyperplasia in Scribtm1.2Phum/Scrib+ mice

reproductive system
increased prostate gland weight ( J:178461 )
• however, treatment with MEK inhibitor PD0325901 restores normal prostate weight
prostate gland hyperplasia ( J:178461 )
• in 7 of 10 mice with a 4.8-fold increase in cell proliferation without a change in the rate of apoptosis
abnormal prostate gland physiology ( J:178461 )
• a 4.8-fold increase in cell proliferation without a change in the rate of apoptosis

neoplasm
increased lung adenoma incidence ( J:216266 )
• 43% incidence of lung adenomas by 540 days of age
• lung tumors range from atypical adenomatous hyperplasia to focal grade 3 lesions
increased lung non-small cell carcinoma incidence ( J:216266 )
• lung adenomas have characteristics of non-small cell lung cancer
increased lung adenocarcinoma incidence ( J:178461 )
• at 540 days, 4 of 8 mice develop lung adenocarcinomas unlike wild-type mice

endocrine/exocrine glands
increased prostate gland weight ( J:178461 )
• however, treatment with MEK inhibitor PD0325901 restores normal prostate weight
prostate gland hyperplasia ( J:178461 )
• in 7 of 10 mice with a 4.8-fold increase in cell proliferation without a change in the rate of apoptosis
abnormal pancreas morphology ( J:178461 )
• at 540 days, one mouse exhibit pancreatic preinvasive ductal lesions unlike wild-type mice
abnormal prostate gland physiology ( J:178461 )
• a 4.8-fold increase in cell proliferation without a change in the rate of apoptosis

respiratory system
increased lung adenoma incidence ( J:216266 )
• 43% incidence of lung adenomas by 540 days of age
• lung tumors range from atypical adenomatous hyperplasia to focal grade 3 lesions
increased lung non-small cell carcinoma incidence ( J:216266 )
• lung adenomas have characteristics of non-small cell lung cancer
increased lung adenocarcinoma incidence ( J:178461 )
• at 540 days, 4 of 8 mice develop lung adenocarcinomas unlike wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory