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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zbtb1m1Btlr
mutation 1, Bruce Beutler
MGI:5300200
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zbtb1m1Btlr/Zbtb1m1Btlr involves: C3H/HeN * C57BL/6J MGI:5300538
cx2
 		Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Zbtb1m1Btlr/Zbtb1m1Btlr 		involves: 129S1/Sv * C3H/HeN * C57BL/6 * C57BL/6J MGI:5300539


Genotype
MGI:5300538
hm1
Allelic
Composition		 Zbtb1m1Btlr/Zbtb1m1Btlr
Genetic
Background		 involves: C3H/HeN * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb1m1Btlr mutation (1 available); any Zbtb1 mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:178820 )
N
• the number of myeloid cells in the spleen is normal
abnormal thymus morphology ( J:178820 )
• thymi lack cortico-medullary definition
abnormal B cell differentiation ( J:178820 )
• mice exhibit an accumulation of B cell progenitors at the Hardy Fraction C stage, with a subsequent reduction of progenitors at the later stages
abnormal T cell differentiation ( J:178820 )
• thymocyte development is impaired from the early thymic precursor stage and beyond
• bone marrow cells exhibit competitive failure of lymphoid reconstitution in Rag1 null mice
decreased B cell number ( J:178820 )
• in the spleen
increased B cell number ( J:178820 )
• 20-fold in the thymus
decreased NK cell number ( J:178820 )
• in the spleen
decreased T cell number ( J:178820 )
• in the spleen
• T cells fail to develop with the exception of T cells that arise from a somatic revertant mutation (cysteine to serine at position 74)
abnormal immune system physiology ( J:178820 )
• mice lack T-independent immune response
• however, T-dependent immune response is normal

hematopoietic system
hematopoietic system phenotype ( J:178820 )
N
• the number of myeloid cells in the spleen is normal
abnormal thymus morphology ( J:178820 )
• thymi lack cortico-medullary definition
abnormal B cell differentiation ( J:178820 )
• mice exhibit an accumulation of B cell progenitors at the Hardy Fraction C stage, with a subsequent reduction of progenitors at the later stages
abnormal T cell differentiation ( J:178820 )
• thymocyte development is impaired from the early thymic precursor stage and beyond
• bone marrow cells exhibit competitive failure of lymphoid reconstitution in Rag1 null mice
decreased B cell number ( J:178820 )
• in the spleen
increased B cell number ( J:178820 )
• 20-fold in the thymus
decreased NK cell number ( J:178820 )
• in the spleen
decreased T cell number ( J:178820 )
• in the spleen
• T cells fail to develop with the exception of T cells that arise from a somatic revertant mutation (cysteine to serine at position 74)

endocrine/exocrine glands
abnormal thymus morphology ( J:178820 )
• thymi lack cortico-medullary definition




Genotype
MGI:5300539
cx2
Allelic
Composition		 Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Zbtb1m1Btlr/Zbtb1m1Btlr
Genetic
Background		 involves: 129S1/Sv * C3H/HeN * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Ast mutation (4 available); any Bcl2l11 mutation (36 available)
Zbtb1m1Btlr mutation (1 available); any Zbtb1 mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
absent T cells ( J:178820 )
• T cells fail to develop

immune system
absent T cells ( J:178820 )
• T cells fail to develop




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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory