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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(SIRPA)1Flv
transgene insertion 1, Richard A Flavell
MGI:5300383
Summary 2 genotypes


Genotype
MGI:5605193
cx1
Allelic
Composition		 Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Tg(SIRPA)1Flv/0
Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic
Background		 involves: 129S4/SvJae * BALB/cAnNTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf1tm1.1(CSF1)Flv mutation (0 available); any Csf1 mutation (48 available)
Csf2/Il3tm1.1(CSF2,IL3)Flv mutation (1 available); any Il3 mutation (31 available)
Il2rgtm1.1Flv mutation (6 available); any Il2rg mutation (178 available)
Rag2tm1.1Flv mutation (6 available); any Rag2 mutation (119 available)
Tg(SIRPA)1Flv mutation (1 available)
Thpotm1.1(TPO)Flv mutation (1 available); any Thpo mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal response to transplant ( J:207289 )
• mice transplanted with human fetal liver-derived hematopoietic CD34+ cells exhibit increased numbers of human myeloid cells (CD33+) in blood and bone marrow as compared to NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz J controls
• peripheral blood is mostly composed of human monocytes
• bone marrow is composed of human monocytes and neutrophils
• monocyte subpopulations are similar to populations found in human peripheral blood and bone marrow
• transplanted mice develop human eosinophils, basophils and dendritic cells in bone marrow and blood
• numbers of human myeloid cells in non lymphoid tissues (lung, liver, colon) are increased by 10 fold that of controls
• numbers of human NK cells found in blood and liver are 10x higher in engrafted mutant as compared to controls
• engrafted tumors exhibit increased numbers of human myelomonocytic cells and are larger in volume as compared to controls
• following LPS injection or Listeria infection, levels of human TNFA, IL6 and IFNB are increased as compared to controls




Genotype
MGI:5605194
cx2
Allelic
Composition		 Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv
Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Tg(SIRPA)1Flv/0
Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic
Background		 involves: 129S4/SvJae * BALB/cAnNTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf1tm1.1(CSF1)Flv mutation (0 available); any Csf1 mutation (48 available)
Csf2/Il3tm1.1(CSF2,IL3)Flv mutation (2 available); any Csf2 mutation (35 available)
Il2rgtm1.1Flv mutation (6 available); any Il2rg mutation (178 available)
Rag2tm1.1Flv mutation (6 available); any Rag2 mutation (119 available)
Tg(SIRPA)1Flv mutation (1 available)
Thpotm1.1(TPO)Flv mutation (1 available); any Thpo mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal response to transplant ( J:207289 )
• mice transplanted with human fetal liver-derived hematopoietic CD34+ cells exhibit increased numbers of human myeloid cells (CD33+) in blood and bone marrow as compared to NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz J controls
• peripheral blood is mostly composed of human monocytes
• bone marrow is composed of human monocytes and neutrophils
• monocyte subpopulations are similar to populations found in human peripheral blood and bone marrow
• transplanted mice develop human eosinophils, basophils and dendritic cells in bone marrow and blood
• numbers of human myeloid cells in non lymphoid tissues (lung, liver, colon) are increased by 10 fold that of controls
• numbers of human NK cells found in blood and liver are 10x higher in engrafted mutant as compared to controls
• engrafted tumors exhibit increased numbers of human myelomonocytic cells and are larger in volume as compared to controls
• following LPS injection or Listeria infection, levels of human TNFA, IL6 and IFNB are increased as compared to controls




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory