Analysis Tools
mortality/aging
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• most mice die within 48 hours of birth
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nervous system
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• reduced proliferating cells in the external granule cell layer at P0 and P5
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• abnormal foliation in serial sagittal sections through the vermis
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• lobes 4 through 5 fail to develop
• lobes 6 through 8 do not divide normally into sublobes
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• at P0, the four principal fissures are absent
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• at P10 and 2 months
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• at P0 and through postnatal development and to adulthood
• the central vermis is severely reduced in size
• however, the lateral cerebellar hemispheres are relatively unaffected
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behavior/neurological
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• in surviving mice
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cellular
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• reduced proliferating cells in the external granule cell layer at P0 and P5
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growth/size/body
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• in surviving mice
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respiratory system
