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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(tetO-Ccnd1*T286A,-luc)10897Kuw
transgene insertion 10897, Kay-Uwe Wagner
MGI:5300556
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ccnd1tm1Wbg/Ccnd1tm1Wbg
Tg(MMTV-tTA)25755Kuw/0
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0 		involves: 129S2/SvPas * FVB/N MGI:5300579
cx2
 		Ccnd1tm1Wbg/Ccnd1tm1Wbg
Tg(MMTVneu)202Mul/0
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0 		involves: 129S2/SvPas * FVB/N MGI:5300587
cx3
 		Ccnd1tm1Wbg/Ccnd1+
Tg(MMTVneu)202Mul/0
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0 		involves: 129S2/SvPas * FVB/N MGI:5300588


Genotype
MGI:5300579
cx1
Allelic
Composition		 Ccnd1tm1Wbg/Ccnd1tm1Wbg
Tg(MMTV-tTA)25755Kuw/0
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)
Tg(MMTV-tTA)25755Kuw mutation (0 available)
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:178842 )
N
• the mammary gland alveolar compartment develop normally

integument




Genotype
MGI:5300587
cx2
Allelic
Composition		 Ccnd1tm1Wbg/Ccnd1tm1Wbg
Tg(MMTVneu)202Mul/0
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)
Tg(MMTVneu)202Mul mutation (2 available)
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 500 days
increased tumor latency ( J:178842 )
• development of palpable tumors in the mammary gland is delayed 3 to 4 months compared to in Ccnd1tm1Wbg/Ccnd1+ Tg(MMTV-PyVT)634Mul Tg(TetO-Ccnd1T286A)10897Kuw mice
• however, latency is the same as in Ccnd1tm1Wbg/Ccnd1tm1Wbg Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 500 days

integument
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 500 days




Genotype
MGI:5300588
cx3
Allelic
Composition		 Ccnd1tm1Wbg/Ccnd1+
Tg(MMTVneu)202Mul/0
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)
Tg(MMTVneu)202Mul mutation (2 available)
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 300 days

integument
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 300 days

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 300 days




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory