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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Alb-F8*R593C)T4Mcal
transgene insertion T4, Michele Calos
MGI:5300683
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		F8tm1Kaz/Y
Tg(Alb-F8*R593C)T4Mcal/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:5304184


Genotype
MGI:5304184
cx1
Allelic
Composition		 F8tm1Kaz/Y
Tg(Alb-F8*R593C)T4Mcal/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F8tm1Kaz mutation (2 available); any F8 mutation (25 available)
Tg(Alb-F8*R593C)T4Mcal mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:178969 )
N
• mutants do not develop anti-factor VIII antibodies following administration of factor VIII as seen in F8tm1Kaz/Y males
• no factor VIII specific antibody secreting cells or memory B cells are present in mice and no factor VIII specific T cell responses are seen, indicating that mutants are tolerant to intravenously administered factor VIII




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory