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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kitltm1.1Sjm
targeted mutation 1.1, Sean J Morrison
MGI:5300819
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kitltm1.1Sjm/Kitltm1.1Sjm BKa.129S6-Kitltm1.1Sjm MGI:5306347
ht2
 		Kitltm1.1Sjm/Kitl+ BKa.129S6-Kitltm1.1Sjm MGI:5306346
cn3
 		Kitltm1.1Sjm/Kitltm2.1Sjm
Leprtm2(cre)Rck/Lepr+
Tg(Tek-cre)12Flv/0 		involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL MGI:5306357
cn4
 		Kitltm1.1Sjm/Kitltm2.1Sjm
Leprtm2(cre)Rck/Lepr+ 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL MGI:5306356


Genotype
MGI:5306347
hm1
Allelic
Composition		 Kitltm1.1Sjm/Kitltm1.1Sjm
Genetic
Background		 BKa.129S6-Kitltm1.1Sjm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm1.1Sjm mutation (1 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

hematopoietic system
anemia ( J:180431 )
• severe
decreased hematopoietic cell number ( J:180431 )
• 8-fold in the liver
abnormal bone marrow cell physiology ( J:180431 )
• bone marrow cells used to repopulate irradiated mice exhibit reduced bone marrow-derived cell production

liver/biliary system
liver hypoplasia ( J:180431 )
• 5-fold




Genotype
MGI:5306346
ht2
Allelic
Composition		 Kitltm1.1Sjm/Kitl+
Genetic
Background		 BKa.129S6-Kitltm1.1Sjm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm1.1Sjm mutation (1 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver hypoplasia ( J:180431 )
• 2-fold




Genotype
MGI:5306357
cn3
Allelic
Composition		 Kitltm1.1Sjm/Kitltm2.1Sjm
Leprtm2(cre)Rck/Lepr+
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm1.1Sjm mutation (1 available); any Kitl mutation (94 available)
Kitltm2.1Sjm mutation (1 available); any Kitl mutation (94 available)
Leprtm2(cre)Rck mutation (1 available); any Lepr mutation (122 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system

growth/size/body
spleen hyperplasia ( J:180431 )




Genotype
MGI:5306356
cn4
Allelic
Composition		 Kitltm1.1Sjm/Kitltm2.1Sjm
Leprtm2(cre)Rck/Lepr+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm1.1Sjm mutation (1 available); any Kitl mutation (94 available)
Kitltm2.1Sjm mutation (1 available); any Kitl mutation (94 available)
Leprtm2(cre)Rck mutation (1 available); any Lepr mutation (122 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased hematopoietic cell number ( J:180431 )
• in the bone marrow and the spleen
• depletion in the bone marrow increases over time

immune system

growth/size/body
enlarged spleen ( J:180431 )
spleen hyperplasia ( J:180431 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory