Phenotypes associated with this allele

• Allele Symbol: Ptpmt1^tm1Ckq
• Allele Name: targeted mutation 1, Cheng-Kui Qu
• Allele ID: MGI:5300821
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptpmt1^tm1Ckq/Ptpmt1^tm1Ckq	B6.Cg-Ptpmt1^tm1Ckq	MGI:5300823

Genotype
MGI:5300823

hm1

• Allelic Composition: Ptpmt1^tm1Ckq/Ptpmt1^tm1Ckq
• Genetic Background: B6.Cg-Ptpmt1^tm1Ckq

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:178313 )

• die at about E7.5

embryo

increased embryonic tissue cell apoptosis ( J:178313 )

• extensive apoptosis at E6.5

• markedly increased apoptotic cells in mutant embryos and ectoplacental cones at E7.5

absent inner cell mass proliferation ( J:178313 )

• the inner cell mass of cultured blastocysts gradually stop growing and die after 6 days in culture

• unable to establish embryonic stem cell clones from blastocysts

embryonic growth retardation ( J:178313 )

• severely retarded with embryos at E7.5 resembling early stage blastocysts

disorganized embryonic tissue ( J:178313 )

• at E6.5

cellular

increased embryonic tissue cell apoptosis ( J:178313 )

• extensive apoptosis at E6.5

• markedly increased apoptotic cells in mutant embryos and ectoplacental cones at E7.5

absent inner cell mass proliferation ( J:178313 )

• the inner cell mass of cultured blastocysts gradually stop growing and die after 6 days in culture

• unable to establish embryonic stem cell clones from blastocysts

growth/size/body

embryonic growth retardation ( J:178313 )

• severely retarded with embryos at E7.5 resembling early stage blastocysts