All Phenotypes Ptpmt1<tm2.1Ckq> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ptpmt1^tm2.1Ckq
targeted mutation 2.1, Cheng-Kui Qu
MGI:5300822

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL	MGI:5485994
cn2	Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL	MGI:5485996
cn3	Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq Tg(Lck-cre)1Cwi/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL	MGI:5485995
cn4	Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq Tg(Mx1-cre)1Cgn/0	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL	MGI:5485992
cn5	Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq Tg(VAV1-cre)1Graf/0	involves: 129S6/SvEvTac * C57BL/6J * SJL	MGI:5485993

Allelic Composition	Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Ptpmt1^tm2.1Ckq mutation (0 available); any Ptpmt1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal aerobic respiration ( J:194929 )

• macrophages exhibit decreased mitochondrial aerobic metabolism at basal levels and maximal reserve capacities compared with control cells

hematopoietic system

hematopoietic system phenotype ( J:194929 )

N	• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors

immune system

immune system phenotype ( J:194929 )

N	• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors • macrophages exhibit normal growth and cell cycle

Allelic Composition	Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Ptpmt1^tm2.1Ckq mutation (0 available); any Ptpmt1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:194929 )

N	• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors

immune system

immune system phenotype ( J:194929 )

N	• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors

Allelic Composition	Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq Tg(Lck-cre)1Cwi/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpmt1^tm2.1Ckq mutation (0 available); any Ptpmt1 mutation (14 available)
Tg(Lck-cre)1Cwi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:194929 )

N	• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors

immune system

immune system phenotype ( J:194929 )

N	• mice exhibit normal myeloid, T lymphoid and B lymphoid lineages and cell cycle of lineage progenitors

Allelic Composition	Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpmt1^tm2.1Ckq mutation (0 available); any Ptpmt1 mutation (14 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:194929 )

• most mice die within 2 to 3 weeks of pIpC treatment

hematopoietic system

hematopoietic system phenotype ( J:194929 )

N	• hematopoietic stem cells in pIpC-treated mice exhibit normal apoptosis rates

decreased common myeloid progenitor cell number ( J:194929 )

• decreased bone marrow myeloid and lymphoid progenitors in pIpC-treated mice

anemia ( J:194929 )

• severe in pIpC-treated mice

abnormal common lymphocyte progenitor cell morphology ( J:194929 )

• decreased bone marrow myeloid and lymphoid progenitors in pIpC-treated mice

pancytopenia ( J:194929 )

• in pIpC-treated mice

increased hematopoietic stem cell number ( J:194929 )

• increased hematopoietic stem cells and multipotent progenitors in the bone marrow of pIpC-treated mice

abnormal hematopoietic stem cell physiology ( J:194929 )

• hematopoietic stem cells (HCS) from pIpC-treated mice fail to differentiate in colony forming assays

• cell-autonomous defect in differentiation and blocked repopulating capabilities in HCS from pIpC-treated mice

• HSCs from pIpC-treated mice accumulate at the G1 phase and exhibit enhanced entry of quiescence

Allelic Composition	Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq Tg(VAV1-cre)1Graf/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpmt1^tm2.1Ckq mutation (0 available); any Ptpmt1 mutation (14 available)
Tg(VAV1-cre)1Graf mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:194929 )

• within 5 to 9 days of birth

• however, mice can be rescued by transplantation of wild-type bone marrow cells

hematopoietic system

small thymus ( J:194929 )

anemia ( J:194929 )

• severe

impaired hematopoiesis ( J:194929 )

• neonatal

decreased bone marrow cell number ( J:194929 )

• 75-fold by P5

pancytopenia ( J:194929 )

increased hematopoietic stem cell number ( J:194929 )

• 30-fold; develops gradually

small spleen ( J:194929 )

immune system

small thymus ( J:194929 )

small spleen ( J:194929 )

endocrine/exocrine glands

small thymus ( J:194929 )

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