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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppargtm1.1(tTA)Jmgr
targeted mutation 1.1, Jonathan M Graff
MGI:5300919
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5581951
cn2
 		Ctnnb1tm2Kem/Ctnnb1+
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5581952
cn3
 		Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
Tg(tetO-HIST1H2BJ/GFP)47Efu/0 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 MGI:5581950
cn4
 		Ctnnb1tm1Mmt/Ctnnb1+
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 MGI:5581956


Genotype
MGI:5581951
cn1
Allelic
Composition		 Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Ppargtm1.1(tTA)Jmgr mutation (1 available); any Pparg mutation (41 available)
Tg(tetO-cre)1Jaw mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:178340 )
N
• mice exhibit normal bone formation and osteoblast surface/numbers
abnormal osteoclast physiology ( J:178340 )
• decreased proliferation of osteoclast precursors
increased bone volume ( J:178340 )
• at 6 months
abnormal trabecular bone morphology ( J:178340 )
• more trabecular bone and bone surface at 6 months
increased bone trabecula number ( J:178340 )
• with reduced spacing at 6 months

hematopoietic system
abnormal osteoclast physiology ( J:178340 )
• decreased proliferation of osteoclast precursors

immune system
abnormal osteoclast physiology ( J:178340 )
• decreased proliferation of osteoclast precursors




Genotype
MGI:5581952
cn2
Allelic
Composition		 Ctnnb1tm2Kem/Ctnnb1+
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Ppargtm1.1(tTA)Jmgr mutation (1 available); any Pparg mutation (41 available)
Tg(tetO-cre)1Jaw mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:178340 )
N
• doxycycline-treated mice exhibit normal numbers of osteoblasts, bone formation and bone mineral apposition rates
increased osteoclast cell number ( J:178340 )
• in doxycycline-treated mice
abnormal osteoclast physiology ( J:178340 )
• doxycycline-treated bone marrow cultures exhibit reduced osteoclast precursor proliferation compared with control cultures
abnormal trabecular bone morphology ( J:178340 )
• decreased bone surface in doxycycline-treated mice
decreased trabecular bone volume ( J:178340 )
• trabecular, cortical and total in doxycycline-treated mice
decreased bone trabecula number ( J:178340 )
• with increased spacing in doxycycline-treated mice
decreased trabecular bone mass ( J:178340 )
• in doxycycline-treated mice
decreased trabecular bone thickness ( J:178340 )
• in doxycycline-treated mice
osteoporosis ( J:178340 )
• in doxycycline-treated mice
increased bone resorption ( J:178340 )
• in doxycycline-treated mice

hematopoietic system
increased osteoclast cell number ( J:178340 )
• in doxycycline-treated mice
abnormal osteoclast physiology ( J:178340 )
• doxycycline-treated bone marrow cultures exhibit reduced osteoclast precursor proliferation compared with control cultures

immune system
increased osteoclast cell number ( J:178340 )
• in doxycycline-treated mice
abnormal osteoclast physiology ( J:178340 )
• doxycycline-treated bone marrow cultures exhibit reduced osteoclast precursor proliferation compared with control cultures




Genotype
MGI:5581950
cn3
Allelic
Composition		 Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
Tg(tetO-HIST1H2BJ/GFP)47Efu/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Ppargtm1.1(tTA)Jmgr mutation (1 available); any Pparg mutation (41 available)
Tg(tetO-cre)1Jaw mutation (6 available)
Tg(tetO-HIST1H2BJ/GFP)47Efu mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoclast differentiation ( J:178340 )
• cultured bone marrow cells contain fewer osteoclast precursors compared with control mice

hematopoietic system
abnormal osteoclast differentiation ( J:178340 )
• cultured bone marrow cells contain fewer osteoclast precursors compared with control mice

cellular
abnormal osteoclast differentiation ( J:178340 )
• cultured bone marrow cells contain fewer osteoclast precursors compared with control mice

immune system
abnormal osteoclast differentiation ( J:178340 )
• cultured bone marrow cells contain fewer osteoclast precursors compared with control mice




Genotype
MGI:5581956
cn4
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1+
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Ppargtm1.1(tTA)Jmgr mutation (1 available); any Pparg mutation (41 available)
Tg(tetO-cre)1Jaw mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:178340 )
N
• doxycycline-treated mice exhibit normal bone formation and numbers of osteoblasts
abnormal osteoclast differentiation ( J:178340 )
• impaired in doxycycline-treated mice
decreased osteoclast cell number ( J:178340 )
• in doxycycline-treated mice
increased bone volume ( J:178340 )
• as early as P15 in doxycycline-treated mice
• 27-fold from 10 months of age in doxycycline-treated mice
increased compact bone volume ( J:178340 )
• in doxycycline-treated mice
abnormal trabecular bone morphology ( J:178340 )
• 4.6-fold increase in trabecular bone surface and a smaller bone surface to bone volume in doxycycline-treated mice
increased trabecular bone volume ( J:178340 )
• trabecular, cortical and total volume as early as P15 in doxycycline-treated mice
increased bone trabecula number ( J:178340 )
• 3.6-fold with reduced trabecular separation in doxycycline-treated mice
increased trabecular bone thickness ( J:178340 )
• 8.5-fold in doxycycline-treated mice
osteopetrosis ( J:178340 )
• severe in doxycycline-treated mice
• in mice following adult onset activation with doxycycline
decreased bone resorption ( J:178340 )
• in doxycycline-treated mice

hematopoietic system
abnormal osteoclast differentiation ( J:178340 )
• impaired in doxycycline-treated mice
extramedullary hematopoiesis ( J:178340 )
• in doxycycline-treated mice
decreased bone marrow cell number ( J:178340 )
• at 4 months in doxycycline-treated mice
absent bone marrow cell ( J:178340 )
• at 10 months in doxycycline-treated mice
decreased osteoclast cell number ( J:178340 )
• in doxycycline-treated mice
increased splenocyte number ( J:178340 )
• gradual in doxycycline-treated mice

cellular
abnormal osteoclast differentiation ( J:178340 )
• impaired in doxycycline-treated mice

immune system
abnormal osteoclast differentiation ( J:178340 )
• impaired in doxycycline-treated mice
decreased osteoclast cell number ( J:178340 )
• in doxycycline-treated mice
increased splenocyte number ( J:178340 )
• gradual in doxycycline-treated mice




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory