Phenotypes associated with this allele

• Allele Symbol: Lepr^tm5Mgmj
• Allele Name: targeted mutation 5, Martin G Myers, Jr
• Allele ID: MGI:5301119
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lepr^tm5Mgmj/Lepr^tm5Mgmj	B6.129-Lepr^tm5Mgmj	MGI:5301171
hm2	Lepr^tm5Mgmj/Lepr^tm5Mgmj	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5696618

Genotype
MGI:5301171

hm1

• Allelic Composition: Lepr^tm5Mgmj/Lepr^tm5Mgmj
• Genetic Background: B6.129-Lepr^tm5Mgmj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:179119 )

N • female mice are fertile

abnormal estrous cycle ( J:179119 )

♀

endocrine/exocrine glands

abnormal insulin secretion ( J:221245 )

♂ • male mice on a high fat diet trend toward impaired insulin secretion after glucose injection

growth/size/body

increased body weight ( J:179119 )

• in female mice on a chow diet

• slightly in mice fed a high-fat diet

adipose tissue

increased total body fat amount ( J:179119 )

• slightly in mice fed a chow diet

behavior/neurological

abnormal eating behavior ( J:179119 )

• slightly in mice fed a high-fat diet

homeostasis/metabolism

abnormal insulin secretion ( J:221245 )

♂ • male mice on a high fat diet trend toward impaired insulin secretion after glucose injection

increased circulating leptin level ( J:179119 )

• slightly in mice fed a chow diet

insulin resistance ( J:221245 )

♂ • elevated insulin at 15 minutes after glucose injection in male mice on a high fat diet

Genotype
MGI:5696618

hm2

• Allelic Composition: Lepr^tm5Mgmj/Lepr^tm5Mgmj
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

growth/size/body

increased body weight ( J:221245 )

• although male body weight on a normal diet is normal, female body weight on the same diet is significantly increased

• on a high fat diet both sexes are slightly heavier than controls

adipose tissue

increased total body fat amount ( J:221245 )

• fat mass slightly increased when fed a high fat diet

homeostasis/metabolism

increased circulating leptin level ( J:221245 )

♀ • circulating leptin levels increase significantly only in females on a high fat diet

increased oxygen consumption ( J:221245 )

♂ • male oxygen consumption is elevated in both light and dark phase

behavior/neurological

increased food intake ( J:221245 )

• increase of 5-10% on a high fat diet with no increase on a normal diet

reproductive system

reproductive system phenotype ( J:221245 )

♀N • first estrus cycle proceeds normally

delayed estrus ( J:221245 )

♀ • second and later estrus cycles are delayed with interval between cycles twice as long as controls