All Phenotypes Mecom<tm2.1Aspe> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mecom^tm2.1Aspe
targeted mutation 2.1, Archibald Perkins
MGI:5301306

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mecom^tm1Aspe/Mecom^tm2.1Aspe Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S1/SvImJ * C57BL/6 * C57BL/6J * CBA	MGI:5301413
cn2	Mecom^tm2.1Aspe/Mecom^tm2.1Aspe Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S1/SvImJ * C57BL/6 * CBA	MGI:5301414

Allelic Composition	Mecom^tm1Aspe/Mecom^tm2.1Aspe Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129S1/SvImJ * C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecom^tm1Aspe mutation (1 available); any Mecom mutation (81 available)
Mecom^tm2.1Aspe mutation (1 available); any Mecom mutation (81 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal bone marrow cell morphology/development ( J:178429 )

• tamoxifen-treated mice lack long-term repopulating cells (or high proliferative potential colony-forming cells; HPP-CFC) unlike wild-type mice

abnormal common myeloid progenitor cell morphology ( J:178429 )

• granulocyte and macrophage progenitors (CFU-G and CFU-M, respectively) are increase compared with wild-type mice

decreased common myeloid progenitor cell number ( J:178429 )

• tamoxifen-treated mice exhibit fewer multipotent progenitors (CFU-GEMM) and granulocyte-macrophage progenitor (CFU-GM) compared with wild-type mice

Allelic Composition	Mecom^tm2.1Aspe/Mecom^tm2.1Aspe Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129S1/SvImJ * C57BL/6 * CBA