Phenotypes associated with this allele

• Allele Symbol: Mecom^tm2.2Aspe
• Allele Name: targeted mutation 2.2, Archibald Perkins
• Allele ID: MGI:5301308
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mecom^tm2.2Aspe/Mecom^tm2.2Aspe	involves: 129 * C57BL/6J * FVB/N	MGI:5301321

Genotype
MGI:5301321

hm1

• Allelic Composition: Mecom^tm2.2Aspe/Mecom^tm2.2Aspe
• Genetic Background: involves: 129 * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:213829 )

• no mice survive longer than 3 days, however mice are born with a normal Mendelian ratio and are indistinguishable from controls at brith

growth/size/body

weight loss ( J:213829 )

• several hours to a few days after birth, mice become weak and lose weight

respiratory system

pulmonary vascular congestion ( J:213829 )

• some pups exhibit congested lungs

behavior/neurological

weakness ( J:213829 )

• several hours to a few days after birth, mice become weak

cardiovascular system

interrupted aortic arch ( J:213829 )

• 4 of 6 embryos exhibit aortic arch formation impairments, showing interrupted aortic arch with a complete discontinuation between the ascending and descending parts of the aorta

pulmonary vascular congestion ( J:213829 )

• some pups exhibit congested lungs

abnormal heart morphology ( J:213829 )

• E15.5 embryos show structural abnormalities in the heart

persistent truncus arteriosus ( J:213829 )

• 3 of 6 embryos exhibit common arterial trunk

double outlet right ventricle ( J:213829 )

• 3 of 6 embryos exhibit double outlet right ventricle

overriding aortic valve ( J:213829 )

• 1 of 6 embryos show overriding aorta

ventricular septal defect ( J:213829 )

• all embryos show ventricular septal defects

hemorrhage ( J:213829 )

• 31% of pups show visible focal hemorrhages in various tissues at birth

hematopoietic system

thrombocytopenia ( J:213829 )

• hypoproliferative thrombocytopenia

decreased leukocyte cell number ( J:213829 )

• mild leukopenia

• however, erythropoiesis is normal in newborns

decreased B cell number ( J:213829 )

• slight reduction in the number of B220+ B-lymphocytes and colony-forming cells in E14.4 fetal livers

decreased hematopoietic stem cell number ( J:213829 )

• the number of KSL (c-Kit+, Sca-1+, lineage-) hematopoietic stem cells is reduced (76%) in fetal livers

decreased hematopoietic precursor cell number ( J:213829 )

• the number of KL-CD34+ (c-Kit+, lineage-,CD34+) progenitor cells is reduced in fetal livers

homeostasis/metabolism

edema ( J:213829 )

• seen in some pups

immune system

decreased leukocyte cell number ( J:213829 )

• mild leukopenia

• however, erythropoiesis is normal in newborns

decreased B cell number ( J:213829 )

• slight reduction in the number of B220+ B-lymphocytes and colony-forming cells in E14.4 fetal livers

abnormal immune system organ morphology ( J:213829 )

• 2 of 6 embryos exhibit small benign bilateral cysts in the jugular lymphatic sacs at E15.5