Phenotypes associated with this allele

• Allele Symbol: Dock1^tm1.1Ysfk
• Allele Name: targeted mutation 1.1, Yoshinori Fukui
• Allele ID: MGI:5301316
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dock1^tm1.1Ysfk/Dock1^tm1.1Ysfk	B6(Cg)-Dock1^tm1.1Ysfk	MGI:5301325

Genotype
MGI:5301325

hm1

• Allelic Composition: Dock1^tm1.1Ysfk/Dock1^tm1.1Ysfk
• Genetic Background: B6(Cg)-Dock1^tm1.1Ysfk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:178190 )

• some embryos are dead at E17.5 and E18.5

prenatal lethality, complete penetrance ( J:178190 )

• no viable homozygous offspring are produced

• homozygous embryos present at all time points tested

muscle

abnormal myogenesis ( J:178190 )

homeostasis/metabolism

edema ( J:178190 )

• severe edema in a large area of the back at E14.5

cardiovascular system

abnormal vascular endothelial cell migration ( J:178190 )

• E12.5 endothelial cells show reduced invasiveness

• migratory response of endothelial cells almost completely lost at E15.5

• "endothelial cushion" from which atrioventricular valves and membranous septa form shows reduced cellularity at E12.5

abnormal vasculogenesis ( J:178190 )

• reduced connections between the superior mesenteric artery and the capillary plexus of the midgut loop at E15.5

• large vessels of the stomach are also poorly developed at E15.5

abnormal heart morphology ( J:178190 )

thick mitral valve cusps ( J:178190 )

• sometimes fused as well

ventricular septal defect ( J:178190 )

• at E14.5

abnormal heart right ventricle outflow tract morphology ( J:178190 )

• double outlet at E14.5

cellular

abnormal vascular endothelial cell migration ( J:178190 )

• E12.5 endothelial cells show reduced invasiveness

• migratory response of endothelial cells almost completely lost at E15.5

• "endothelial cushion" from which atrioventricular valves and membranous septa form shows reduced cellularity at E12.5