Phenotypes associated with this allele

• Allele Symbol: Rgs6^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:5301342
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rgs6^tm1Lex/Rgs6^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:5301442

Genotype
MGI:5301442

hm1

• Allelic Composition: Rgs6^tm1Lex/Rgs6^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased heart rate ( J:178182 , J:178185 )

• larger and more persistent bradycardia than controls after carbachol treatment (J:178182)

• mild resting bradycardia (J:178182)

• enhanced carbachol induced bradycardia as compared to controls (J:178185)

abnormal impulse conducting system conduction ( J:178182 )

• current deactivation kinetics for acetylcholine activated potassium currents is slower in myocytes

• activation kinetics of acetylcholine activated potassium currents is delayed but only at lower carbachol concentrations

abnormal sinoatrial node conduction ( J:178182 , J:178185 )

• carbachol currents show significantly delayed deactivation (J:178182)

• spontaneous action potential firing rate in the sinoatrial node is inhibited (J:178185)

• reduced activation-deactivation of acetyl choline activated potassium current (J:178185)