Phenotypes associated with this allele

• Allele Symbol: Tg(Slco1c1-icre/ERT2)1Mash
• Allele Name: transgene insertion 1, Markus Schwaninger
• Allele ID: MGI:5301361
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Map3k7^tm1Aki/Map3k7^tm1Aki Tg(Slco1c1-icre/ERT2)1Mash/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5305853
cn2	Map3k7^tm1Aki/Map3k7^tm1Aki Tg(Slco1c1-icre/ERT2)1Mash/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5305854
cn3	Kras^tm4Tyj/Kras^+ Tg(Slco1c1-icre/ERT2)1Mash/0	involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB	MGI:7435433

Genotype
MGI:5305853

cn1

• Allelic Composition: Map3k7^tm1Aki/Map3k7^tm1Aki; Tg(Slco1c1-icre/ERT2)1Mash/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:179050 )

N • intravenous administration of IL-1beta induces reduction in food intake (IL-1beta-induced anorexia over 22 hours; this is similar to response of control mice

lethargy ( J:179050 )

• mutants exhibit reduced lethargy relative to controls in response to intravenous IL-1beta administration

decreased locomotor activity ( J:179050 )

• injection of IL-1beta at 10 am reduced spontaneous locomotion in mutants the next night, response is weaker than in controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:179050 )

N • mice have normal body temperature

N • corticosterone plasma levels rise to same extent as controls in response to IL-1beta administration

impaired febrile response ( J:179050 )

• IL-1beta induces only a short-lasting fever response in mutants compared to controls; however, early fever response remains intact

growth/size/body

growth/size/body region phenotype ( J:179050 )

N • intravenous administration of IL-1beta induces weight loss in mutants over 22 hours; this is similar to response of control mice

Genotype
MGI:5305854

cn2

• Allelic Composition: Map3k7^tm1Aki/Map3k7^tm1Aki; Tg(Slco1c1-icre/ERT2)1Mash/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

behavior/neurological

behavior/neurological phenotype ( J:179050 )

N • in response to IL-1beta administration, inhibition of locomotion is similar in mutants and controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:179050 )

N • induced fever response to IL-1beta administration is similar to controls

Genotype
MGI:7435433

cn3

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Tg(Slco1c1-icre/ERT2)1Mash/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB

cardiovascular system

abnormal brain vasculature morphology ( J:312482 )

• vasculature surrounding brain arteriovenous malformations is abnormal in tamoxifen-administered mice, with vessels appearing tortuous and dilated, similar to niduses associated with these lesions in human patients

arteriovenous malformation ( J:312482 )

• mice administered tamoxifen at P1 show presence of brain arteriovenous malformations at 8 weeks of age occurring in the cortex, just anterior to the cerebellum, as well as near the olfactory bulb

intracranial hemorrhage ( J:312482 )

• mice administered tamoxifen at P1 only rarely show intracranial hemorrhage (1 of 28 mice) at 8 weeks of age

nervous system

abnormal brain vasculature morphology ( J:312482 )

• vasculature surrounding brain arteriovenous malformations is abnormal in tamoxifen-administered mice, with vessels appearing tortuous and dilated, similar to niduses associated with these lesions in human patients

intracranial hemorrhage ( J:312482 )

• mice administered tamoxifen at P1 only rarely show intracranial hemorrhage (1 of 28 mice) at 8 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
arteriovenous malformations of the brain		DOID:0060688	OMIM:108010	J:312482