Analysis Tools
hematopoietic system
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• eosinophil numbers in blood, spleen, and bone marrow are similar to controls, while neutrophil numbers in blood, bone marrow and peritoneal cavity are also similar to controls; a modest increase in neutrophils is observed in the spleen
• no signfiicant changes in T cell or B cell number are detected; absolute numbers of lymphocytes or myeloid cells in the blood are not significantly changed
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• mice exhibit a mild macrocytic anemia
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• significantly fewer basphils are observed in the spleen, bone marrow, and blood of 3-10 month-old mice compared with controls
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• mice show approximately a 31% reduction in erythrocytes in blood
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• a 24% reduction relative to controls is observed
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• 6 week to 10 month-old mice show significant reductions in mast cell numbers in almost all tissues and organs examined, except in the spleen
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immune system
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• significantly fewer basphils are observed in the spleen, bone marrow, and blood of 3-10 month-old mice compared with controls
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• 6 week to 10 month-old mice show significant reductions in mast cell numbers in almost all tissues and organs examined, except in the spleen
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• IgE-dependent chronic allergic inflammation (CAI) is reduced; leukocyte infiltration into the dermis is almost absent and basophils are not detected 3 days after IgE challenge
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• in IgE-treated mice, IgE-dependent passive cutaneous anaphylaxis (PCA) is reduced compared to controls; tissue swelling is reduced relative to treated controls at 30 minutes after antigen challenge
• mast cell numbers in dermis of ear pinnae 6 hours after treatment with IgE are low and no detectable increase in dermal leukocytes is observed
• in IgE-dependent passive systemic anaphylaxis (PSA), IgE-sensitized mutants are essentially un reactive to challenge with IgE injection, whereas controls exhibit hypothermia and sometimes death in response to identical challenge
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