Phenotypes associated with this allele

• Allele Symbol: Jam2^tm1.2Rha
• Allele Name: targeted mutation 1.2, Ralf H Adams
• Allele ID: MGI:5301450
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jam2^tm1.2Rha/Jam2^tm1.2Rha	B6.Cg-Jam2^tm1.2Rha	MGI:5301451

Genotype
MGI:5301451

hm1

• Allelic Composition: Jam2^tm1.2Rha/Jam2^tm1.2Rha
• Genetic Background: B6.Cg-Jam2^tm1.2Rha

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by ionizing radiation ( J:178387 )

increased susceptibility to xenobiotic induced morbidity/mortality ( J:178387 )

• in 5-FU-treated mice

hematopoietic system

abnormal bone marrow cell morphology/development ( J:178387 )

• mice exhibit a 2-fold reduction in endothelial cells, mesenchymal stem cells, and osteoblasts in the bone marrow compared with wild-type mice

• mice exhibit increased numbers of common myeloid progenitors (CMPs) and granulocytic/monocytic-restricted progenitors (GMPs) compared with wild-type mice

increased bone marrow cell number ( J:178387 )

abnormal hematopoietic stem cell morphology ( J:178387 )

• decreased frequency but normal absolute numbers

abnormal hematopoietic stem cell physiology ( J:178387 )

• hematopoietic stem cells exhibit slightly increased percentage of G1 and S/G2/M cells compared to in wild-type mice

• hematopoietic stem cells exhibit impaired engraftment and survival after myelo-ablation (via 5-FU treatment) compared with wild-type cells

• hematopoietic stem cells exhibit exacerbated responses to mobilizing agents compared with wild-type cells

homeostasis/metabolism

increased mortality induced by ionizing radiation ( J:178387 )

increased susceptibility to xenobiotic induced morbidity/mortality ( J:178387 )

• in 5-FU-treated mice

skeleton

decreased osteoblast cell number ( J:178387 )

• in the bone marrow