All Phenotypes Rc3h1<tm1.2Mass> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rc3h1^tm1.2Mass
targeted mutation 1.2, Marc Schmidt-Supprian
MGI:5301574

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rc3h1^tm1.2Mass/Rc3h1^tm1.2Mass	involves: C57BL/6 * CBA * CD-1 * NZB * SJL	MGI:5301606
hm2	Rc3h1^tm1.2Mass/Rc3h1^tm1.2Mass	involves: C57BL/6 * CBA * NZB * SJL	MGI:5301605

Allelic Composition	Rc3h1^tm1.2Mass/Rc3h1^tm1.2Mass
Genetic Background	involves: C57BL/6 * CBA * CD-1 * NZB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rc3h1^tm1.2Mass mutation (0 available); any Rc3h1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Growth retardation and increased spleen size in Rc3h1^tm1.2Mass/Rc3h1^tm1.2Mass mice

mortality/aging

preweaning lethality, incomplete penetrance ( J:177784 )

• few mice survive to adulthood

immune system

immune system phenotype ( J:177784 )

N	• mice exhibit normal spontaneous germinal center formation, autoantibody production, and autoimmunity

enlarged spleen ( J:177784 )

increased spleen weight ( J:177784 )

abnormal effector T cell morphology ( J:177784 )

• mice exhibit an increase in CD8 effector-like T cells in the spleen compared with control mice

limbs/digits/tail

curly tail ( J:177784 )

• at birth and sometimes corrected later on

hematopoietic system

enlarged spleen ( J:177784 )

increased spleen weight ( J:177784 )

abnormal effector T cell morphology ( J:177784 )

• mice exhibit an increase in CD8 effector-like T cells in the spleen compared with control mice

growth/size/body

decreased body weight ( J:177784 )

postnatal growth retardation ( J:177784 )

enlarged spleen ( J:177784 )

increased spleen weight ( J:177784 )

Allelic Composition	Rc3h1^tm1.2Mass/Rc3h1^tm1.2Mass
Genetic Background	involves: C57BL/6 * CBA * NZB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rc3h1^tm1.2Mass mutation (0 available); any Rc3h1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Curly tail, skin, soft tissue and bone defect, and alveoli that are not properly expanded in Rc3h1^tm1.2Mass/Rc3h1^tm1.2Mass mice

mortality/aging

neonatal lethality, complete penetrance ( J:177784 )

• mice die within 6 hours of birth

skeleton

abnormal vertebral column morphology ( J:177784 )

• caudal spinal column malformations

respiratory system

primary atelectasis ( J:177784 )

immune system

abnormal thymus development ( J:177784 )

• embryonic thymus transplanted into athymic C57BL/6 nude mice exhibit atrophy without affecting T cell selection compared with mice transplanted with wild-type thymus

limbs/digits/tail

curly tail ( J:177784 )

hematopoietic system

abnormal thymus development ( J:177784 )

• embryonic thymus transplanted into athymic C57BL/6 nude mice exhibit atrophy without affecting T cell selection compared with mice transplanted with wild-type thymus

endocrine/exocrine glands

abnormal thymus development ( J:177784 )

• embryonic thymus transplanted into athymic C57BL/6 nude mice exhibit atrophy without affecting T cell selection compared with mice transplanted with wild-type thymus

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