All Phenotypes Rc3h1<tm1.1Mass> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL	MGI:5301604
cn2	Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺	involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL	MGI:5301602
cn3	Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2 * NZB * SJL	MGI:5301603
cn4	Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass Rc3h2^{tm1c(KOMP)Wtsi}/Rc3h2^{tm1c(KOMP)Wtsi} Tg(Cd4-cre)1Cwi/?	involves: C57BL/6N * DBA/2	MGI:5510239

Allelic Composition	Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Rc3h1^tm1.1Mass mutation (0 available); any Rc3h1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged spleen ( J:177784 )

• due to expansion of B cells, regulatory T cells, CD4 and CD8 effector-like T cell, and eosinophils

increased spleen weight ( J:177784 )

increased eosinophil cell number ( J:177784 )

• in the spleen

increased B cell number ( J:177784 )

• in the spleen

increased regulatory T cell number ( J:177784 )

• in the spleen

abnormal effector T cell morphology ( J:177784 )

• mice exhibit an increase in CD4 and CD8 effector-like T cells in the spleen compared with control mice

hematopoietic system

enlarged spleen ( J:177784 )

• due to expansion of B cells, regulatory T cells, CD4 and CD8 effector-like T cell, and eosinophils

increased spleen weight ( J:177784 )

increased eosinophil cell number ( J:177784 )

• in the spleen

increased B cell number ( J:177784 )

• in the spleen

increased regulatory T cell number ( J:177784 )

• in the spleen

abnormal effector T cell morphology ( J:177784 )

• mice exhibit an increase in CD4 and CD8 effector-like T cells in the spleen compared with control mice

growth/size/body

enlarged spleen ( J:177784 )

• due to expansion of B cells, regulatory T cells, CD4 and CD8 effector-like T cell, and eosinophils

increased spleen weight ( J:177784 )

Allelic Composition	Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
Genetic Background	involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10^{Tg(Vav1-icre)A2Kio} mutation (3 available); any Commd10 mutation (24 available)
Rc3h1^tm1.1Mass mutation (0 available); any Rc3h1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Increased spleen size in Rc3h1^tm1.1Mass/Rc3h1^tm1.1MassCommd10^{Tg(Vav1-icre)A2Kio}/0 mice

immune system

immune system phenotype ( J:177784 )

N	• mice exhibit normal T cell development and autoimmunity

enlarged spleen ( J:177784 )

• 1.5-fold but not as severe as in Rc3h1^san homozygotes

increased spleen weight ( J:177784 )

• 1.5-fold

spleen hyperplasia ( J:177784 )

• 1.5-fold

abnormal B cell differentiation ( J:177784 )

• in the bone marrow

decreased immature B cell number ( J:177784 )

increased eosinophil cell number ( J:177784 )

• in the spleen

decreased B cell number ( J:177784 )

• immature and re-circulating B cells

increased regulatory T cell number ( J:177784 )

• in the spleen

increased macrophage cell number ( J:177784 )

• in the spleen

abnormal effector T cell morphology ( J:177784 )

• increased numbers in the spleen

abnormal spleen B cell follicle morphology ( J:177784 )

• some are disrupted

increased splenocyte number ( J:177784 )

• 1.5-fold

abnormal germinal center B cell physiology ( J:177784 )

• mice exhibit increased spontaneous germinal center formation compared with control mice

decreased IgA level ( J:177784 )

decreased IgG1 level ( J:177784 )

increased IgG2b level ( J:177784 )

decreased IgG3 level ( J:177784 )

hematopoietic system

enlarged spleen ( J:177784 )

• 1.5-fold but not as severe as in Rc3h1^san homozygotes

increased spleen weight ( J:177784 )

• 1.5-fold

spleen hyperplasia ( J:177784 )

• 1.5-fold

abnormal B cell differentiation ( J:177784 )

• in the bone marrow

decreased immature B cell number ( J:177784 )

decreased bone marrow cell number ( J:177784 )

increased eosinophil cell number ( J:177784 )

• in the spleen

decreased B cell number ( J:177784 )

• immature and re-circulating B cells

increased regulatory T cell number ( J:177784 )

• in the spleen

increased macrophage cell number ( J:177784 )

• in the spleen

abnormal effector T cell morphology ( J:177784 )

• increased numbers in the spleen

abnormal spleen B cell follicle morphology ( J:177784 )

• some are disrupted

increased splenocyte number ( J:177784 )

• 1.5-fold

abnormal germinal center B cell physiology ( J:177784 )

• mice exhibit increased spontaneous germinal center formation compared with control mice

decreased IgA level ( J:177784 )

decreased IgG1 level ( J:177784 )

increased IgG2b level ( J:177784 )

decreased IgG3 level ( J:177784 )

growth/size/body

enlarged spleen ( J:177784 )

• 1.5-fold but not as severe as in Rc3h1^san homozygotes

increased spleen weight ( J:177784 )

• 1.5-fold

spleen hyperplasia ( J:177784 )

• 1.5-fold

Allelic Composition	Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: C57BL/6 * DBA/2 * NZB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rc3h1^tm1.1Mass mutation (0 available); any Rc3h1 mutation (42 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:177784 )

N	• mice exhibit normal T cell development • unlike in Rc3h1^san homozygotes, mice do not exhibit increased follicular T cell differentiation or germinal center formation • mice exhibit normal autoimmunity

increased eosinophil cell number ( J:177784 )

• doubled

increased CD8-positive, alpha-beta T cell number ( J:177784 )

• with a short-lived effector-like phenotype

increased macrophage cell number ( J:177784 )

• the number of monocytic macrophages is doubled compared to in control mice

hematopoietic system

increased eosinophil cell number ( J:177784 )

• doubled

increased CD8-positive, alpha-beta T cell number ( J:177784 )

• with a short-lived effector-like phenotype

increased macrophage cell number ( J:177784 )

• the number of monocytic macrophages is doubled compared to in control mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal immune system cell morphology ( J:196136 )

abnormal B cell number ( J:196136 )

• B220+ B cells are almost undetectable

• spleens often with reduced B cell counts

increased germinal center B cell number ( J:196136 )

increased T follicular helper cell number ( J:196136 )

• both frequency and absolute numbers are increased

decreased T cell number ( J:196136 )

decreased CD4-positive, alpha-beta T cell number ( J:196136 )

• significant decrease in total cell numbers for CD4+ cells

• significant decrease in naive CD4+ T cell numbers

decreased CD8-positive, alpha-beta T cell number ( J:196136 )

• significant decrease in naive CD8+ T cell numbers

abnormal immune system organ morphology ( J:196136 )

abnormal spleen morphology ( J:196136 )

enlarged spleen ( J:196136 )

• splemomegaly at a young age

abnormal spleen B cell follicle morphology ( J:196136 )

• unorganized or absent follicular structures in the spleen

abnormal spleen periarteriolar lymphoid sheath morphology ( J:196136 )

• T cell areas of the spleen are unorganized, particularly those affecting CD8+ cells

enlarged lymph nodes ( J:196136 )

• at a young age

abnormal immune system physiology ( J:196136 )

• severe immune dysregulation

increased T cell proliferation ( J:196136 )

• increased activation of both CD4+ and CD8+ T cells

hematopoietic system

increased T cell proliferation ( J:196136 )

• increased activation of both CD4+ and CD8+ T cells

abnormal B cell number ( J:196136 )

• B220+ B cells are almost undetectable

• spleens often with reduced B cell counts

increased germinal center B cell number ( J:196136 )

increased T follicular helper cell number ( J:196136 )

• both frequency and absolute numbers are increased

decreased T cell number ( J:196136 )

decreased CD4-positive, alpha-beta T cell number ( J:196136 )

• significant decrease in total cell numbers for CD4+ cells

• significant decrease in naive CD4+ T cell numbers

decreased CD8-positive, alpha-beta T cell number ( J:196136 )

• significant decrease in naive CD8+ T cell numbers

abnormal spleen morphology ( J:196136 )

enlarged spleen ( J:196136 )

• splemomegaly at a young age

abnormal spleen B cell follicle morphology ( J:196136 )

• unorganized or absent follicular structures in the spleen

abnormal spleen periarteriolar lymphoid sheath morphology ( J:196136 )

• T cell areas of the spleen are unorganized, particularly those affecting CD8+ cells

growth/size/body

enlarged spleen ( J:196136 )

• splemomegaly at a young age

cellular

increased T cell proliferation ( J:196136 )

• increased activation of both CD4+ and CD8+ T cells

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