Phenotypes associated with this allele

• Allele Symbol: Wwc1^tm1.1Rlh
• Allele Name: targeted mutation 1.1, Richard L Huganir
• Allele ID: MGI:5301655
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wwc1^tm1.1Rlh/Wwc1^tm1.1Rlh	involves: 129 * C57BL/6	MGI:5301656

Genotype
MGI:5301656

hm1

• Allelic Composition: Wwc1^tm1.1Rlh/Wwc1^tm1.1Rlh
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:178552 )

• during the training session and 24 hours after training

• however, mice exhibit normal conditioning immediately after training

impaired cued conditioning behavior ( J:178552 )

• during the training session and 24 hours after training

• however, mice exhibit normal conditioning immediately after training

nervous system

reduced long-term potentiation ( J:178552 )

• long term potentiation induced with theta-burst stimulation in adult mice is delayed compared to in wild-type mice

• however, juvenile mice exhibit normal synaptic plasticity

reduced long-term depression ( J:178552 )

• long term depression induced by NMDA in adult is delayed compared to in wild-type mice

• however, juvenile mice exhibit normal synaptic plasticity