Phenotypes associated with this allele

• Allele Symbol: Maml3^tm1Mkit
• Allele Name: targeted mutation 1, Motoo Kitagawa
• Allele ID: MGI:5301728
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Maml3^tm1Mkit/Maml3^tm1Mkit	involves: 129P2/OlaHsd * C57BL/6	MGI:5301731
cx2	Maml1^tm1Mkit/Maml1^tm1Mkit Maml3^tm1Mkit/Maml3^tm1Mkit	B6.129P2-Maml3^tm1Mkit Maml1^tm1Mkit	MGI:5301733
cx3	Maml1^tm1Mkit/Maml1^tm1Mkit Maml3^tm1Mkit/Maml3^tm1Mkit	involves: 129P2/OlaHsd * C57BL/6	MGI:5301732

Genotype
MGI:5301731

hm1

• Allelic Composition: Maml3^tm1Mkit/Maml3^tm1Mkit
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:178680 )

• viable and fertile with no gross abnormalities and normal splenocyte numbers

Genotype
MGI:5301733

cx2

• Allelic Composition: Maml1^tm1Mkit/Maml1^tm1Mkit; Maml3^tm1Mkit/Maml3^tm1Mkit
• Genetic Background: B6.129P2-Maml3^tm1Mkit Maml1^tm1Mkit

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:178680 )

• Background Sensitivity: lethality begins earlier compared to mice on a mixed 129P2/OlaHsd and C57BL/6 background

• underrepresented at E10.5 and absent by E11.5

Genotype
MGI:5301732

cx3

• Allelic Composition: Maml1^tm1Mkit/Maml1^tm1Mkit; Maml3^tm1Mkit/Maml3^tm1Mkit
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:178680 )

• survive up to E12.5

• Background Sensitivity: embryos survive longer compared to mice on an inbred C57BL/6 background

embryo

abnormal pharyngeal arch morphology ( J:178680 )

• at E9.5 to E10.5 embryos have a single branchial arch

decreased embryo size ( J:178680 )

• most embryos are smaller than littermate controls at E9.5 to E10.5

impaired somite development ( J:178680 )

• at E9.5

abnormal visceral yolk sac morphology ( J:178680 )

• at E9.5 to E10.5 the yolk sac has a rough texture and the vessels are barely visible

cardiovascular system

abnormal angiogenesis ( J:178680 )

• at E9.5 to E10.5 blood vessels are present but the structure is more primitive and less finely branched in the head region

abnormal heart looping ( J:178680 )

• poorly folded hearts are often seen in embryos at E9.5 to E10.5

enlarged pericardium ( J:178680 )

• often seen in embryos at E9.5 to E10.5

nervous system

abnormal neuron proliferation ( J:178680 )

• accelerated neurogenesis in the neural tube, forebrain and hindbrain

craniofacial

abnormal pharyngeal arch morphology ( J:178680 )

• at E9.5 to E10.5 embryos have a single branchial arch

growth/size/body

decreased embryo size ( J:178680 )

• most embryos are smaller than littermate controls at E9.5 to E10.5

cellular

abnormal neuron proliferation ( J:178680 )

• accelerated neurogenesis in the neural tube, forebrain and hindbrain