Phenotypes associated with this allele

• Allele Symbol: Fbxo4^tm1.1Jadi
• Allele Name: targeted mutation 1.1, J Alan Diehl
• Allele ID: MGI:5301830
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxo4^tm1.1Jadi/Fbxo4^tm1.1Jadi	Not Specified	MGI:5301867
ht2	Fbxo4^tm1.1Jadi/Fbxo4^+	Not Specified	MGI:5301866

Genotype
MGI:5301867

hm1

• Allelic Composition: Fbxo4^tm1.1Jadi/Fbxo4^tm1.1Jadi
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:178645 )

• mean survival is 23 months

neoplasm

increased tumor incidence ( J:178645 )

• mice develop tumors of lymphoblastic lineage with frequent intense myeloid proliferation due to severe extramedullary hematopoiesis and early myeloid malignancy

increased mammary gland tumor incidence ( J:178645 )

• mammary epithelium tumors/mammary carcinomas

increased hepatocellular carcinoma incidence ( J:178645 )

increased hemangioma incidence ( J:178645 )

• liver and lungs

increased hepatic hemangioma incidence ( J:178645 )

increased lymphoma incidence ( J:178645 )

• large cell lymphoblastic lymphoma and dendritic cell tumors/histiocytic sarcomas of the spleen, thymus, and lintestinal wall/mesentary

increased histiocytic sarcoma incidence ( J:178645 )

• dendritic cell tumors (spleen and thymus)/histiocytic sarcomas of the spleen, thymus, and intestinal wall/mesentary

increased myeloid sarcoma incidence ( J:178645 )

• early myeloid tumors

increased uterus tumor incidence ( J:178645 )

♀ • uterine epithelium tumors

hematopoietic system

myeloid hyperplasia ( J:178645 )

• intense myeloid proliferation in the spleen and liver

extramedullary hematopoiesis ( J:178645 )

• spleen and liver

cellular

increased fibroblast proliferation ( J:178645 )

• in mouse embryonic fibroblasts during early passages

immune system

myeloid hyperplasia ( J:178645 )

• intense myeloid proliferation in the spleen and liver

liver/biliary system

increased hepatic hemangioma incidence ( J:178645 )

increased hepatocellular carcinoma incidence ( J:178645 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:178645 )

• mammary epithelium tumors/mammary carcinomas

integument

increased mammary gland tumor incidence ( J:178645 )

• mammary epithelium tumors/mammary carcinomas

reproductive system

increased uterus tumor incidence ( J:178645 )

♀ • uterine epithelium tumors

Genotype
MGI:5301866

ht2

• Allelic Composition: Fbxo4^tm1.1Jadi/Fbxo4⁺
• Genetic Background: Not Specified

mortality/aging

premature death ( J:178645 )

• mean survival is 23 months

neoplasm

increased tumor incidence ( J:178645 )

• mice develop tumors of lymphoblastic lineage with frequent intense myeloid proliferation due to severe extramedullary hematopoiesis and early myeloid malignancy

increased mammary gland tumor incidence ( J:178645 )

• mammary epithelium tumors/mammary carcinomas

increased hepatocellular carcinoma incidence ( J:178645 )

increased hemangioma incidence ( J:178645 )

• liver and lungs

increased hepatic hemangioma incidence ( J:178645 )

increased lymphoma incidence ( J:178645 )

• large cell lymphoblastic lymphoma and dendritic cell tumors/histiocytic sarcomas of the spleen, thymus, and lintestinal wall/mesentary

increased histiocytic sarcoma incidence ( J:178645 )

• dendritic cell tumors (spleen and thymus)/histiocytic sarcomas of the spleen, thymus, and intestinal wall/mesentary

increased myeloid sarcoma incidence ( J:178645 )

• early myeloid tumors

increased uterus tumor incidence ( J:178645 )

♀ • uterine epithelium tumors

hematopoietic system

myeloid hyperplasia ( J:178645 )

• intense myeloid proliferation in the spleen and liver

extramedullary hematopoiesis ( J:178645 )

• spleen and liver

immune system

myeloid hyperplasia ( J:178645 )

• intense myeloid proliferation in the spleen and liver

liver/biliary system

increased hepatic hemangioma incidence ( J:178645 )

increased hepatocellular carcinoma incidence ( J:178645 )

reproductive system

increased uterus tumor incidence ( J:178645 )

♀ • uterine epithelium tumors

integument

increased mammary gland tumor incidence ( J:178645 )

• mammary epithelium tumors/mammary carcinomas

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:178645 )

• mammary epithelium tumors/mammary carcinomas