Phenotypes associated with this allele

• Allele Symbol: Cd79a^tm1.1Rsky
• Allele Name: targeted mutation 1.1, Klaus Rajewsky
• Allele ID: MGI:5301876
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd79a^tm1.1Rsky/Cd79a^tm1.1Rsky	involves: C57BL/6	MGI:5301879

Genotype
MGI:5301879

hm1

• Allelic Composition: Cd79a^tm1.1Rsky/Cd79a^tm1.1Rsky
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:179254 )

N • mice exhibit normal immune response to NP-CGG

N • mice exhibit response to LPS

increased immature B cell number ( J:179254 )

• by half in the bone marrow

increased transitional stage B cell number ( J:179254 )

• by half in the bone marrow

increased transitional stage T1 B cell number ( J:179254 )

increased transitional stage T2 B cell number ( J:179254 )

increased transitional stage T3 B cell number ( J:179254 )

decreased mature B cell number ( J:179254 )

decreased marginal zone B cell number ( J:179254 )

increased pre-B cell number ( J:179254 )

• by a half with the greatest increase in small pre-B cells

abnormal humoral immune response ( J:179254 )

• mice exhibit a 4- to 5-fold increase in IgG2b and IgG2c producing cells in the bone marrow compared with wild-type mice

decreased IgG2b level ( J:179254 )

• following NP-Ficoll immunization

increased IgG2b level ( J:179254 )

• 4-fold in unimmunized mice due to a 4- to 5-fold increase in secreting cells in the bone marrow

• at 8 to 10 weeks mice exhibit low levels of IgG2c and IgG2b antibodies against NP, ssDNA, and the metabolic enzyme glucose phosphate isomerase

• however, 9 month old mice exhibit normal levels

decreased IgG2c level ( J:179254 )

• following NP-Ficoll immunization

increased IgG2c level ( J:179254 )

• 4-fold in unimmunized mice due to a 4- to 5-fold increase in secreting cells in the bone marrow

• at 8 to 10 weeks mice exhibit low levels of IgG2c and IgG2b antibodies against NP, ssDNA, and the metabolic enzyme glucose phosphate isomerase

• however, 9 month old mice exhibit normal levels

decreased IgG3 level ( J:179254 )

• only at 7 days after NP-Ficoll treatment

increased anti-single stranded DNA antibody level ( J:179254 )

• at 8 to 10 weeks mice exhibit low levels of IgG2c and IgG2b antibodies against NP, ssDNA, and the metabolic enzyme glucose phosphate isomerase

• however, 9 month old mice exhibit normal levels and mice do not exhibit any autoimmune response associated injury

hematopoietic system

hematopoietic system phenotype ( J:179254 )

N • bone marrow cellularity is normal

N • total numbers of B cells in the spleen is normal

increased immature B cell number ( J:179254 )

• by half in the bone marrow

increased transitional stage B cell number ( J:179254 )

• by half in the bone marrow

increased transitional stage T1 B cell number ( J:179254 )

increased transitional stage T2 B cell number ( J:179254 )

increased transitional stage T3 B cell number ( J:179254 )

decreased mature B cell number ( J:179254 )

decreased marginal zone B cell number ( J:179254 )

increased pre-B cell number ( J:179254 )

• by a half with the greatest increase in small pre-B cells

decreased IgG2b level ( J:179254 )

• following NP-Ficoll immunization

increased IgG2b level ( J:179254 )

• 4-fold in unimmunized mice due to a 4- to 5-fold increase in secreting cells in the bone marrow

• at 8 to 10 weeks mice exhibit low levels of IgG2c and IgG2b antibodies against NP, ssDNA, and the metabolic enzyme glucose phosphate isomerase

• however, 9 month old mice exhibit normal levels

decreased IgG2c level ( J:179254 )

• following NP-Ficoll immunization

increased IgG2c level ( J:179254 )

• 4-fold in unimmunized mice due to a 4- to 5-fold increase in secreting cells in the bone marrow

• at 8 to 10 weeks mice exhibit low levels of IgG2c and IgG2b antibodies against NP, ssDNA, and the metabolic enzyme glucose phosphate isomerase

• however, 9 month old mice exhibit normal levels

decreased IgG3 level ( J:179254 )

• only at 7 days after NP-Ficoll treatment