Phenotypes associated with this allele

• Allele Symbol: Ppp5c^tm1.2Rhon
• Allele Name: targeted mutation 1.2, Richard E Honkanen
• Allele ID: MGI:5301885
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp5c^tm1.2Rhon/Ppp5c^tm1.2Rhon	B6.129X1-Ppp5c^tm1.2Rhon	MGI:5301890
hm2	Ppp5c^tm1.2Rhon/Ppp5c^tm1.2Rhon	either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J * FVB/N)	MGI:5301889

Genotype
MGI:5301890

hm1

• Allelic Composition: Ppp5c^tm1.2Rhon/Ppp5c^tm1.2Rhon
• Genetic Background: B6.129X1-Ppp5c^tm1.2Rhon

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:178164 )

• mice are slightly underrepresented

reproductive system

decreased litter size ( J:178164 )

cellular

abnormal cell morphology ( J:178164 )

• mouse embryonic fibroblasts fail to thrive in conventional medium with erratic growth and irregular phenotypes

abnormal cell adhesion ( J:178164 )

• within a few days of culture, mouse embryonic fibroblasts detach and die

decreased fibroblast proliferation ( J:178164 )

• mouse embryonic fibroblasts fail to thrive in conventional medium with erratic growth and irregular phenotypes

• however, enriched medium improves growth in culture following transformation with SV40 large T antigen

immune system

enlarged spleen ( J:178164 )

• in 1 year old female, but not male, mice

growth/size/body

decreased body weight ( J:178164 )

• in male mice after 2 months

• however, female mice exhibit normal body weight

enlarged spleen ( J:178164 )

• in 1 year old female, but not male, mice

hematopoietic system

enlarged spleen ( J:178164 )

• in 1 year old female, but not male, mice

Genotype
MGI:5301889

hm2

• Allelic Composition: Ppp5c^tm1.2Rhon/Ppp5c^tm1.2Rhon
• Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J * FVB/N)

normal phenotype

no abnormal phenotype detected ( J:178164 )

• mice are viable and fertile with no discernable aberrant phenotypes observed in young (8 weeks) animals