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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Scgb1a1-rtTA)2Jaw
transgene insertion 2, Jeffrey A Whitsett
MGI:5301895
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Elavl1tm1Lix/Elavl1tm1Lix
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0 		involves: 129 * C57BL/6 MGI:5543893
cn2
 		Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0 		involves: 129 * C57BL/6 * FVB/N MGI:5301912
cn3
 		Adam17tm1.1Wesh/Adam17tm1.1Wesh
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0 		involves: 129 * C57BL/6 * FVB/N MGI:5571468
cn4
 		Adam17tm1.1Wesh/Adam17tm1.1Wesh
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0
Twist2tm1.1(cre)Dor/Twist2+ 		involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:5571470


Genotype
MGI:5543893
cn1
Allelic
Composition		 Elavl1tm1Lix/Elavl1tm1Lix
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl1tm1Lix mutation (0 available); any Elavl1 mutation (43 available)
Tg(Scgb1a1-rtTA)2Jaw mutation (1 available)
Tg(tetO-cre)1Jaw mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased inflammatory response ( J:204952 )
• reduced pulmonary inflammation in mice treated with doxycycline and intranasal rIL17
lung inflammation ( J:204952 )
• reduced pulmonary inflammation in mice treated with doxycycline and intranasal rIL17

respiratory system
lung inflammation ( J:204952 )
• reduced pulmonary inflammation in mice treated with doxycycline and intranasal rIL17




Genotype
MGI:5301912
cn2
Allelic
Composition		 Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Scgb1a1-rtTA)2Jaw mutation (1 available)
Tg(tetO-cre)1Jaw mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:179352 )
N
• doxycycline-treated mice do not exhibit perinatal toxicity

respiratory system
respiratory system phenotype ( J:179352 )
N
• doxycycline-treated mice do not exhibit lung pathology or dysfunction
• doxycycline-treated mice exhibit minimal focal airspace enlargement unlike Tg(Scgb1a1-rtTA)1Jaw mice




Genotype
MGI:5571468
cn3
Allelic
Composition		 Adam17tm1.1Wesh/Adam17tm1.1Wesh
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1.1Wesh mutation (0 available); any Adam17 mutation (64 available)
Tg(Scgb1a1-rtTA)2Jaw mutation (1 available)
Tg(tetO-cre)1Jaw mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:210193 )
N
• doxycycline-treated mice exhibit normal neonatal survival

respiratory system
abnormal lung vasculature morphology ( J:210193 )
• reduced pulmonary capillary formation in doxycycline-treated mice
abnormal lung saccule morphology ( J:210193 )
• at E18.5, doxycycline-treated mice exhibit reduced terminal sacs and thickened surrounding mesenchyme in the peripheral lung compared with control mice
• larger but fewer sacs at P1 in doxycycline-treated mice
• however, morphology at P14 and P30 is normal
thick lung-associated mesenchyme ( J:210193 )
• at E18.5 in doxycycline-treated mice
abnormal lung epithelium morphology ( J:210193 )
• impaired epithelial cell differentiation in doxycycline-treated mice

cellular
decreased cell proliferation ( J:210193 )
• at P1, but not P30, in the lungs of doxycycline-treated mice

cardiovascular system
abnormal lung vasculature morphology ( J:210193 )
• reduced pulmonary capillary formation in doxycycline-treated mice




Genotype
MGI:5571470
cn4
Allelic
Composition		 Adam17tm1.1Wesh/Adam17tm1.1Wesh
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0
Twist2tm1.1(cre)Dor/Twist2+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1.1Wesh mutation (0 available); any Adam17 mutation (64 available)
Tg(Scgb1a1-rtTA)2Jaw mutation (1 available)
Tg(tetO-cre)1Jaw mutation (6 available)
Twist2tm1.1(cre)Dor mutation (1 available); any Twist2 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:210193 )
N
• doxycycline-treated mice exhibit normal neonatal survival

respiratory system
abnormal lung vasculature morphology ( J:210193 )
• reduced pulmonary capillary formation in doxycycline-treated mice
abnormal lung saccule morphology ( J:210193 )
• doxycycline-treated mice exhibit enlarged airspaces with fewer number of saccules and reduced epithelial cell differentiation compared with control mice

cellular
decreased cell proliferation ( J:210193 )
• in the lungs of doxycycline-treated mice

cardiovascular system
abnormal lung vasculature morphology ( J:210193 )
• reduced pulmonary capillary formation in doxycycline-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory