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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Kcne1-cre/ERT2)1Imos
transgene insertion 1, Ivan P Moskowitz
MGI:5301931
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tbx5tm1.2Jse/Tbx5tm1.2Jse
Tg(Kcne1-cre/ERT2)1Imos/0
involves: 129S4/SvJaeSor * CD-1 MGI:5474054
cn2
Tbx5tm1.2Jse/Tbx5tm1.2Jse
Tg(Kcne1-cre/ERT2)1Imos/0
involves: CD-1 MGI:5474053


Genotype
MGI:5474054
cn1
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tbx5tm1.2Jse/Tbx5tm1.2Jse
Tg(Kcne1-cre/ERT2)1Imos/0
Genetic
Background
involves: 129S4/SvJaeSor * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
Tbx5tm1.2Jse mutation (0 available); any Tbx5 mutation (29 available)
Tg(Kcne1-cre/ERT2)1Imos mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• tamoxifen-treated mutants have ventricular conduction system (VCS) cellular fate maps indistinguishable from Tbx5-sufficient animals indicating that defects in conditional animals do not result from loss of VCS cells




Genotype
MGI:5474053
cn2
Allelic
Composition
Tbx5tm1.2Jse/Tbx5tm1.2Jse
Tg(Kcne1-cre/ERT2)1Imos/0
Genetic
Background
involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx5tm1.2Jse mutation (0 available); any Tbx5 mutation (29 available)
Tg(Kcne1-cre/ERT2)1Imos mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• sudden death occurring within 5 weeks of tamoxifen administration (at 6 weeks) is observed
• one mouse that developed spontaneous ventricular tachycardia died suddenly prior to any electrophysiological testing
• following tamoxifen treatment starting at 6 weeks, animals demonstrate sudden death as soon as 5 weeks post administration

cardiovascular system
N
• mutants have similar contractile function to controls; mice display immediate recovery of normal cardiac function after episodes of spontaneous ventricular tachycardia
• displayed by some tamoxifen-treated mutants; in ambulatory studies and electrophysiologic (EP) studies, spontaneous monomorphic ventricular tachycardia episodes are observed in some mice
• mice show significantly increased susceptibility to ventricular tachycardia after burst stimulation in EP studies
• significant arrhythmias are observed in tamoxifen-treated mutants, including Mobitz type II second-degree AV block (indicating infranodal conduction system disease)
• premature ventricular contractions (PVCs) numbering more than 100 per 24 hour period are detected in more than half of mutant mice
• severe conduction slowing is observed in tamoxifen-treated animals 4-5 weeks after tamoxifen administration; the PR interval and QRS duration are significantly increased compared to controls
• slowed conductance through the His bundle is detected; non-ventricular conduction system (VCS) function is not altered





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory