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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gdpd5tm1Itl
targeted mutation 1, inGenious Targeting Laboratory
MGI:5302018
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gdpd5tm1Itl/Gdpd5tm1.1Itl
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ 		involves: 129S1/Sv * 129/Sv * 129X1/SvJ * C57BL/6J MGI:5302059


Genotype
MGI:5302059
cn1
Allelic
Composition		 Gdpd5tm1Itl/Gdpd5tm1.1Itl
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdpd5tm1.1Itl mutation (0 available); any Gdpd5 mutation (37 available)
Gdpd5tm1Itl mutation (0 available); any Gdpd5 mutation (37 available)
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:178550 )
N
• mice treated with tamoxifen after neurogenesis (at E10.5) exhibit normal motor pool formation
abnormal neuron differentiation ( J:178550 )
• mice treated with tamoxifen at E8.5 exhibit delayed motor neuron formation compared with control mice
decreased motor neuron number ( J:178550 )
• at E12.5, mice treated with tamoxifen at E8.5 exhibit fewer Isl1/2+ and vasti, adductor longus and magnus, and posterior gracilis muscle motor neurons compared with control mice
• at E14.5, mice treated with tamoxifen at E8.5 exhibit fewer Isl1/2+ and vasti muscle motor neurons compared with control mice
• however, motor neurons in adductor longus and magnus and posterior gracilis muscles recover by E14.5

cellular
abnormal neuron differentiation ( J:178550 )
• mice treated with tamoxifen at E8.5 exhibit delayed motor neuron formation compared with control mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory