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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mir21atm1.1Mer
targeted mutation 1.1, Marc E Rothenberg
MGI:5302027
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mir21atm1.1Mer/Mir21atm1.1Mer B6.129S1-Mir21atm1.1Mer MGI:5302107
hm2
 		Mir21atm1.1Mer/Mir21atm1.1Mer involves: 129S1/Sv * C57BL/6 * FVB/N MGI:5302106


Genotype
MGI:5302107
hm1
Allelic
Composition		 Mir21atm1.1Mer/Mir21atm1.1Mer
Genetic
Background		 B6.129S1-Mir21atm1.1Mer
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir21atm1.1Mer mutation (0 available); any Mir21a mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to type IV hypersensitivity reaction ( J:179235 )
• increased foot pad thickness and foot pad weight after stimulation




Genotype
MGI:5302106
hm2
Allelic
Composition		 Mir21atm1.1Mer/Mir21atm1.1Mer
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir21atm1.1Mer mutation (0 available); any Mir21a mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal interferon level ( J:179235 )
• increased IFNgamma in bronchoalveolar lavage fluid after allergic challenge
abnormal interleukin level ( J:179235 )
• increased IL12a in bronchoalveolar lavage fluid after allergic challenge
• decreased IL4 in bronchoalveolar lavage fluid after allergic challenge
increased susceptibility to type I hypersensitivity reaction ( J:179235 )
• increased IFNgamma, CXCL9, IL12a in bronchoalveolar lavage fluid after allergic challenge
• reduced IL4 and CCL17 in bronchoalveolar lavage fluid after allergic challenge
• significantly reduced eosinophil levels in bronchoalveolar lavage fluid and lung tissue after allergic challenge (OVA)
increased interferon-gamma secretion ( J:179235 )
• by stimulated CD4+ cells
increased interleukin-12 secretion ( J:179235 )
• increased secretion of IL12 by dendritic cells after LPS or LPS and IFNgamma stimulation
decreased interleukin-4 secretion ( J:179235 )
• by stimulated CD4+ cells

homeostasis/metabolism
abnormal interferon level ( J:179235 )
• increased IFNgamma in bronchoalveolar lavage fluid after allergic challenge
abnormal interleukin level ( J:179235 )
• decreased IL4 in bronchoalveolar lavage fluid after allergic challenge
• increased IL12a in bronchoalveolar lavage fluid after allergic challenge




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory