All Phenotypes Mir21a<tm1.1Mer> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mir21a^tm1.1Mer
targeted mutation 1.1, Marc E Rothenberg
MGI:5302027

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir21a^tm1.1Mer/Mir21a^tm1.1Mer	B6.129S1-Mir21a^tm1.1Mer	MGI:5302107
hm2	Mir21a^tm1.1Mer/Mir21a^tm1.1Mer	involves: 129S1/Sv * C57BL/6 * FVB/N	MGI:5302106

Allelic Composition	Mir21a^tm1.1Mer/Mir21a^tm1.1Mer
Genetic Background	B6.129S1-Mir21a^tm1.1Mer

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir21a^tm1.1Mer mutation (0 available); any Mir21a mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to type IV hypersensitivity reaction ( J:179235 )

• increased foot pad thickness and foot pad weight after stimulation

Allelic Composition	Mir21a^tm1.1Mer/Mir21a^tm1.1Mer
Genetic Background	involves: 129S1/Sv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir21a^tm1.1Mer mutation (0 available); any Mir21a mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal cytokine level ( J:179235 )

abnormal interferon level ( J:179235 )

• increased IFNgamma in bronchoalveolar lavage fluid after allergic challenge

abnormal interleukin level ( J:179235 )

• increased IL12a in bronchoalveolar lavage fluid after allergic challenge

• decreased IL4 in bronchoalveolar lavage fluid after allergic challenge

increased susceptibility to type I hypersensitivity reaction ( J:179235 )

• increased IFNgamma, CXCL9, IL12a in bronchoalveolar lavage fluid after allergic challenge

• reduced IL4 and CCL17 in bronchoalveolar lavage fluid after allergic challenge

• significantly reduced eosinophil levels in bronchoalveolar lavage fluid and lung tissue after allergic challenge (OVA)

abnormal cytokine secretion ( J:179235 )

increased interferon-gamma secretion ( J:179235 )

• by stimulated CD4+ cells

increased interleukin-12 secretion ( J:179235 )

• increased secretion of IL12 by dendritic cells after LPS or LPS and IFNgamma stimulation

decreased interleukin-4 secretion ( J:179235 )

• by stimulated CD4+ cells

homeostasis/metabolism

abnormal cytokine level ( J:179235 )

abnormal interferon level ( J:179235 )

• increased IFNgamma in bronchoalveolar lavage fluid after allergic challenge

abnormal interleukin level ( J:179235 )

• increased IL12a in bronchoalveolar lavage fluid after allergic challenge

• decreased IL4 in bronchoalveolar lavage fluid after allergic challenge

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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