All Phenotypes Usp2<tm1.1Bjc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Usp2^tm1.1Bjc
targeted mutation 1.1, Joseph C Besharse
MGI:5302030

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp2^tm1.1Bjc/Usp2^tm1.1Bjc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5302032
cx2	Bmal1^tm1Bra/Bmal1⁺ Usp2^tm1.1Bjc/Usp2⁺	involves: 129 * C57BL/6	MGI:5302035

Allelic Composition	Usp2^tm1.1Bjc/Usp2^tm1.1Bjc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp2^tm1.1Bjc mutation (1 available); any Usp2 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyperactivity ( J:177916 )

• display increased activity during subjective night when maintained in constant darkness

abnormal circadian behavior period ( J:177916 )

• under conditions of constant light, period length increases more slowly in response to lower irradiance levels compared to controls

• however, under conditions of constant darkness period length is not dfferent from controls

delayed circadian behavior phase ( J:177916 )

• under conditions of constant light, mice exhibit a dramatic delay in activity onset at the lowest irradiance level tested

• significantly enhanced phase delays to light exposure beginning at expected dark (ZT12) at low irradiance levels but not at higher irradiance levels

Allelic Composition	Bmal1^tm1Bra/Bmal1⁺ Usp2^tm1.1Bjc/Usp2⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmal1^tm1Bra mutation (1 available); any Bmal1 mutation (137 available)
Usp2^tm1.1Bjc mutation (1 available); any Usp2 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

delayed circadian behavior phase ( J:177916 )

• significantly enhanced phase delays to light exposure beginning at expected dark (ZT12) at low irradiance levels but not at higher irradiance levels

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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