All Phenotypes Pomt2<tm1.1Hhu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pomt2^tm1.1Hhu/Pomt2^tm1.1Hhu Emx1^tm1(cre)Krj/Emx1⁺	involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J	MGI:5302860
cn2	Pomt2^tm1.1Hhu/Pomt2^tm1.1Hhu H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * CBA/J	MGI:5302859
cn3	Pomt2^tm1.1Hhu/Pomt2^tm1.1Hhu Tg(GFAP-cre)25Mes/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:5302861

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal radial glial cell morphology ( J:179356 )

• radial glial cells are disrupted during neocortical development

• radial glial cell processes extend beyond the disruptions of the pial basement membrane

abnormal forebrain morphology ( J:179356 )

• mice exhibit lamination defects with an indistinct layer I unlike in wild-type mice

• the two cerebral hemispheres are fused

• layers II/III, IV, V, and VI cannot be identified

abnormal Cajal-Retzius cell morphology ( J:179356 )

• Cajal-Retzius cells are disrupted during neocortical development

• unlike in wild-type mice, Cajal-Retzius cells are located between the diffuse cell zone and the cortical plate

• in some regions Cajal-Retzius cells are absent in some regions

abnormal Ammon gyrus morphology ( J:179356 )

• 2 mice exhibit lamination defects of pyramidal cells in all CA fields of the Ammon's horn with some pyramidal neurons displaced

abnormal hippocampus CA3 region morphology ( J:179356 )

• 10 of 13 mice exhibit dispersion of CA3 of the Ammon's horn with CA3 cells

abnormal dentate gyrus morphology ( J:179356 )

• wavy inferior blade

abnormal hippocampus layer morphology ( J:179356 )

• lamination defects

abnormal neocortex morphology ( J:179356 )

• mice exhibit ectopic fibroblasts in the upper half of the neocortex

astrocytosis ( J:179356 )

• in the upper half of the neocortex

cellular

abnormal radial glial cell morphology ( J:179356 )

• radial glial cells are disrupted during neocortical development

• radial glial cell processes extend beyond the disruptions of the pial basement membrane

abnormal basement membrane morphology ( J:179356 )

• the pial basement membrane and glia limitans are disrupted during development and in adult mice compared to in wild-type mice

Allelic Composition	Pomt2^tm1.1Hhu/Pomt2^tm1.1Hhu H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Pomt2^tm1.1Hhu mutation (1 available); any Pomt2 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:179356 )

N	• mice exhibit normal meninges of the neocortex, pial basement membrane, and hippocampus

Allelic Composition	Pomt2^tm1.1Hhu/Pomt2^tm1.1Hhu Tg(GFAP-cre)25Mes/0
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomt2^tm1.1Hhu mutation (1 available); any Pomt2 mutation (38 available)
Tg(GFAP-cre)25Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar granule cell migration ( J:179356 )

• some granule cells fail to migrate in the cerebellum

• however, forebrain architecture is normal

abnormal cerebellum morphology ( J:179356 )

• adult mice exhibit breaches in the pial basement membrane and the glia limitans in limited areas at the midline between the cerebral hemispheres compared to in wild-type mice

cellular

abnormal cerebellar granule cell migration ( J:179356 )

• some granule cells fail to migrate in the cerebellum

• however, forebrain architecture is normal

abnormal basement membrane morphology ( J:179356 )

• adult mice exhibit breaches in the pial basement membrane and the glia limitans in limited areas at the midline between the cerebral hemispheres compared to in wild-type mice

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