Phenotypes associated with this allele

• Allele Symbol: Crbn^tm1.1Jjh
• Allele Name: targeted mutation 1.1, Joseph Higgins
• Allele ID: MGI:5302187
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Crbn^tm1.1Jjh/Crbn^tm1.1Jjh	B6(Cg)-Crbn^tm1.1Jjh/J	MGI:6315952
cn2	Crbn^tm1.1Jjh/Crbn^tm1.1Jjh Tg(Camk2a-cre)T29-1Stl/0	involves: C57BL/6	MGI:5302203

Genotype
MGI:6315952

cn1

• Allelic Composition: Crbn^tm1.1Jjh/Crbn^tm1.1Jjh
• Genetic Background: B6(Cg)-Crbn^tm1.1Jjh/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:259276 )

• mice injected with an adenovirus expressing cre recombinase into the bilateral dorsal hippocampus show reduced percentage of time freezing during a 24 hour contextual fear conditioning test, indicating a memory deficit

impaired spatial learning ( J:259276 )

• mice injected with an adenovirus expressing cre recombinase into the bilateral dorsal hippocampus exhibit impaired learning in the Morris water maze, with mice taking longer to locate the hidden platform

• mice injected with an adenovirus expressing cre recombinase into the bilateral dorsal hippocampus exhibit increased latency to find the hidden platform during Y-maze training

abnormal long-term spatial reference memory ( J:259276 )

• mice injected with an adenovirus expressing cre recombinase into the bilateral dorsal hippocampus exhibit impaired memory in the Morris water maze probe test

Genotype
MGI:5302203

cn2

• Allelic Composition: Crbn^tm1.1Jjh/Crbn^tm1.1Jjh; Tg(Camk2a-cre)T29-1Stl/0
• Genetic Background: involves: C57BL/6

behavior/neurological

behavior/neurological phenotype ( J:179427 )

N • mice exhibit normal basal locomotion and anxiety-like behaviors

impaired contextual conditioning behavior ( J:179427 )

• mice freeze significantly less than control mice in a contextual fear conditioning task, indicating deficit it associative learning

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive intellectual developmental disorder		DOID:0060308	OMIM:PS249500	J:179427