Phenotypes associated with this allele

• Allele Symbol: Tg(Crx-cre/ERT2)1Tfur
• Allele Name: transgene insertion 1, Takahisa Furukawa
• Allele ID: MGI:5302219
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rax^tm1.1Tfur/Rax^tm1.1Tfur Tg(Crx-cre/ERT2)1Tfur/0	involves: 129S6/SvEvTac * C3H * C57BL/6	MGI:5311350
cn2	Nmnat1^tm1c(EUCOMM)Wtsi/Nmnat1^tm1c(EUCOMM)Wtsi Tg(Crx-cre/ERT2)1Tfur/0	involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N	MGI:6272876

Genotype
MGI:5311350

cn1

• Allelic Composition: Rax^tm1.1Tfur/Rax^tm1.1Tfur; Tg(Crx-cre/ERT2)1Tfur/0
• Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

retina hypoplasia ( J:177908 )

• retina size at E15.5 is significantly smaller than wild type

Genotype
MGI:6272876

cn2

• Allelic Composition: Nmnat1^{tm1c(EUCOMM)Wtsi}/Nmnat1^{tm1c(EUCOMM)Wtsi}; Tg(Crx-cre/ERT2)1Tfur/0
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

nervous system

short photoreceptor outer segment ( J:267630 )

retina photoreceptor degeneration ( J:267630 )

• by P28, most photoreceptor cells are degenerated and the outer nuclear layer is absent in the retina

vision/eye

abnormal retina morphology ( J:267630 )

• retinal lamination defects are seen at P6

short photoreceptor outer segment ( J:267630 )

retina photoreceptor degeneration ( J:267630 )

• by P28, most photoreceptor cells are degenerated and the outer nuclear layer is absent in the retina

retina outer nuclear layer degeneration ( J:267630 )

• progressive thinning of the outer nuclear layer

decreased total retina thickness ( J:267630 )

• reduction in overall retinal thickness is apparent by P15