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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lzts2tm1.1Zsu
targeted mutation 1.1, Zijie Sun
MGI:5302222
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lzts2tm1.1Zsu/Lzts2tm1.1Zsu B6.Cg-Lzts2tm1.1Zsu MGI:5302224


Genotype
MGI:5302224
hm1
Allelic
Composition
Lzts2tm1.1Zsu/Lzts2tm1.1Zsu
Genetic
Background
B6.Cg-Lzts2tm1.1Zsu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lzts2tm1.1Zsu mutation (0 available); any Lzts2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Lzts2tm1.1Zsu/Lzts2tm1.1Zsu mice exhibit kidney and urinary tract anomalies

renal/urinary system
• between 4 and 12 months of age most mice develop some abnormalities in the urinary tract
• multiple macroscopic and microscopic cysts are seen in some (4 of 21) mice
• cysts originate mainly from the collecting ducts
• lack of glomerular structures in some mice
• expression analysis indicates changes in the adhesion properties of the tubular epithelial cells
• double renal pelvis in some neonates
• seen at E17.5
• some mice display left, right, or bilateral kidney hydronephrosis at 4 to 12 months of age
• in some mice
• duplicated left kidney in some mice
• mild dilation in some mice
• double ureters are seen at E17.5
• duplicated right ureters in some mice between 4 and 12 months
• at E17.5
• in some mice
• abnormal urinary tract development is seen in most mice at 4 to 12 months of age
• at E11.5 ectopic ureteric buds are present which are more anterior to the normal location

embryo
• at E10.5 the entire end of the Wolffian duct is much broader and bifurcated

reproductive system
• malformed left seminal vesicle in some mice
• left seminal vesicle ectasia in some mice
• left uterine horn pyometra in some mice

endocrine/exocrine glands
• malformed left seminal vesicle in some mice
• left seminal vesicle ectasia in some mice

growth/size/body
• multiple macroscopic and microscopic cysts are seen in some (4 of 21) mice
• cysts originate mainly from the collecting ducts

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
urinary system disease DOID:18 J:178154





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory