renal/urinary system
• between 4 and 12 months of age most mice develop some abnormalities in the urinary tract
|
kidney cyst
(
J:178154
)
• multiple macroscopic and microscopic cysts are seen in some (4 of 21) mice
• cysts originate mainly from the collecting ducts
|
• lack of glomerular structures in some mice
|
• expression analysis indicates changes in the adhesion properties of the tubular epithelial cells
|
• double renal pelvis in some neonates
|
• seen at E17.5
• some mice display left, right, or bilateral kidney hydronephrosis at 4 to 12 months of age
|
• in some mice
|
• duplicated left kidney in some mice
|
• mild dilation in some mice
|
• double ureters are seen at E17.5
• duplicated right ureters in some mice between 4 and 12 months
|
hydroureter
(
J:178154
)
• at E17.5
|
short ureter
(
J:178154
)
• in some mice
|
• abnormal urinary tract development is seen in most mice at 4 to 12 months of age
|
• at E11.5 ectopic ureteric buds are present which are more anterior to the normal location
|
embryo
• at E10.5 the entire end of the Wolffian duct is much broader and bifurcated
|
reproductive system
• malformed left seminal vesicle in some mice
|
• left seminal vesicle ectasia in some mice
|
• left uterine horn pyometra in some mice
|
endocrine/exocrine glands
• malformed left seminal vesicle in some mice
|
• left seminal vesicle ectasia in some mice
|
growth/size/body
kidney cyst
(
J:178154
)
• multiple macroscopic and microscopic cysts are seen in some (4 of 21) mice
• cysts originate mainly from the collecting ducts
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
urinary system disease | DOID:18 | J:178154 |