All Phenotypes Dll4<tm2.1Vlcg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dll4^tm2.1Vlcg
targeted mutation 2.1, Velocigene
MGI:5302387

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dll4^tm2.1Vlcg/Dll4^tm2.1Vlcg	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5546215
cn2	Dll4^tm2.1Vlcg/Dll4⁺ Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac	MGI:5302388
cn3	Dll4^tm2.1Vlcg/Dll4⁺ Tg(Nanog-cre)#Vlcg/0	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5546216
cn4	Dll4^tm2.1Vlcg/Dll4^tm2.1Vlcg Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg}/Gt(ROSA)26Sor⁺	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5546217

Allelic Composition	Dll4^tm2.1Vlcg/Dll4^tm2.1Vlcg
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4^tm2.1Vlcg mutation (0 available); any Dll4 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:200671 )

Allelic Composition	Dll4^tm2.1Vlcg/Dll4⁺ Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4^tm2.1Vlcg mutation (0 available); any Dll4 mutation (27 available)
Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal induced retina neovascularization ( J:177797 )

• retinal capillaries from tamoxifen-treated mice are more resistant to oxygen-induced vaso-obliteration compared with control capillaries

abnormal vascular regression ( J:177797 )

• tamoxifen-treated mice exhibit reduced capillary regression during normal developmental capillary remodeling compared with control mice

vision/eye

abnormal induced retina neovascularization ( J:177797 )

• retinal capillaries from tamoxifen-treated mice are more resistant to oxygen-induced vaso-obliteration compared with control capillaries

cellular

abnormal vascular regression ( J:177797 )

• tamoxifen-treated mice exhibit reduced capillary regression during normal developmental capillary remodeling compared with control mice

Allelic Composition	Dll4^tm2.1Vlcg/Dll4⁺ Tg(Nanog-cre)#Vlcg/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4^tm2.1Vlcg mutation (0 available); any Dll4 mutation (27 available)
Tg(Nanog-cre)#Vlcg mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal angiogenesis ( J:200671 )

• severe as in Dll4^tm1Nwg heterozygotes

embryo

abnormal embryo development ( J:200671 )

• authors state that mice phenocopy Dll4^tm1Nwg heterozygotes

Allelic Composition	Dll4^tm2.1Vlcg/Dll4^tm2.1Vlcg Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4^tm2.1Vlcg mutation (0 available); any Dll4 mutation (27 available)
Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:200671 )

• abrogated maturation in mice treated with tamoxifen at P5

vision/eye

abnormal retina vasculature morphology ( J:200671 )

• abrogated maturation in mice treated with tamoxifen at P5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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