Phenotypes associated with this allele

• Allele Symbol: Angptl4^tm1Vlcg
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:5302391
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Angptl4^tm1Vlcg/Angptl4^tm1Vlcg	Not Specified	MGI:5302399

Genotype
MGI:5302399

hm1

• Allelic Composition: Angptl4^tm1Vlcg/Angptl4^tm1Vlcg
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Perturbation of endothelial junction integrity in Angptl4^tm1Vlcg/Angptl4^tm1Vlcg pups

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:177790 )

• fewer than expected mice are present at E11.5 and E13.5

prenatal lethality, incomplete penetrance ( J:177790 )

• fewer than expected neonates survive

cardiovascular system

abnormal capillary morphology ( J:177790 )

• larger diameter in the retina than in control mice

abnormal retina blood vessel morphology ( J:177790 )

• retina exhibit increased vein and capillary diameters, increased vascular density, decreased number of branch points, delayed pericyte coverage, and increased permeability compared with control retina

• endothelial cell tight junctions in mature retinal vascular plexus are loosely organized unlike in control retina

abnormal induced retina neovascularization ( J:177790 )

• retinal vasculature is protected from oxygen-induced obliteration compared to in control retina

• following oxygen-induced, retinal vasculature exhibit impaired neovascularization and decreased pericyte coverage compared to in control retina

• however, oxygen-induced vascular loss is normal

abnormal pericyte morphology ( J:177790 )

• pericyte spreading and coverage in retinal vasculature is delayed compared to in control retina

decreased angiogenesis ( J:177790 )

• retina exhibit decreased mean number of filopodia bursts in the vascular front compared with control retina

• retina exhibit increased vascular density and decreased number of branch points compared with control retina

abnormal vein morphology ( J:177790 )

• larger diameter in the retina than in control mice

increased vascular permeability ( J:177790 )

• in retinal vasculature

vision/eye

abnormal retina blood vessel morphology ( J:177790 )

• retina exhibit increased vein and capillary diameters, increased vascular density, decreased number of branch points, delayed pericyte coverage, and increased permeability compared with control retina

• endothelial cell tight junctions in mature retinal vascular plexus are loosely organized unlike in control retina

abnormal induced retina neovascularization ( J:177790 )

• retinal vasculature is protected from oxygen-induced obliteration compared to in control retina

• following oxygen-induced, retinal vasculature exhibit impaired neovascularization and decreased pericyte coverage compared to in control retina

• however, oxygen-induced vascular loss is normal