All Phenotypes Mc3r<tm1Butl> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mc3r^tm1Butl/Mc3r^tm1Butl	B6.Cg-Mc3r^tm1Butl	MGI:5302395
cn2	Mc3r^tm1Butl/Mc3r^tm1Butl Tg(Nes-cre)1Kln/0	B6.Cg-Mc3r^tm1Butl Tg(Nes-Cre)1Kln	MGI:5302397
cn3	Mc3r^tm1Butl/Mc3r^tm1Butl Tg(Nr5a1-cre)2Lowl/0	involves: C57BL/6J * FVB/NJ	MGI:5302396

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased lean body mass ( J:178147 )

• at 8 weeks of age on a standard chow diet

increased susceptibility to diet-induced obesity ( J:178147 )

• accumulation of fat mass is more pronounced in females fed a high fat diet compared to diet matched controls

adipose tissue

increased total body fat amount ( J:178147 )

• increase in fat mass at 8 weeks of age on a standard chow diet

• accumulation of fat mass is more pronounced in females fed a high fat diet compared to diet matched controls

homeostasis/metabolism

increased circulating insulin level ( J:178147 )

increased circulating leptin level ( J:178147 )

decreased circulating triglyceride level ( J:178147 )

• lower levels of total triglycerides

abnormal energy homeostasis ( J:178147 )

• under a restricted feeding protocol more food is required to protect mice from weight loss exceeding 15% of initial body weight

decreased energy expenditure ( J:178147 )

• subtle lower energy expenditure during the mid dark period

• decrease in energy expenditure per kg of body weight

• non-resting energy expenditure is reduced but resting energy expenditure is normal

increased susceptibility to diet-induced obesity ( J:178147 )

• accumulation of fat mass is more pronounced in females fed a high fat diet compared to diet matched controls

decreased respiratory quotient ( J:178147 )

• the respiratory exchange ratio is reduced

behavior/neurological

abnormal locomotor activation ( J:178147 )

• food anticipatory activity is attenuated

decreased locomotor activity ( J:178147 )

• during the dark period

immune system

increased inflammatory response ( J:178147 )

• significant increases the serum levels of monocyte chemoattractant protein-1 (Mcp1) and resistin indicating a mild state of inflammation

Allelic Composition	Mc3r^tm1Butl/Mc3r^tm1Butl Tg(Nes-cre)1Kln/0
Genetic Background	B6.Cg-Mc3r^tm1Butl Tg(Nes-Cre)1Kln

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc3r^tm1Butl mutation (1 available); any Mc3r mutation (31 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal body fat mass ( J:178147 )

• increase in fat mass in mice on a standard diet is attenuated compared to homozygous mice not expressing the cre transgene

decreased lean body mass ( J:178147 )

• on a standard chow diet

increased susceptibility to diet-induced obesity ( J:178147 )

adipose tissue

abnormal body fat mass ( J:178147 )

• increase in fat mass in mice on a standard diet is attenuated compared to homozygous mice not expressing the cre transgene

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:178147 )

Allelic Composition	Mc3r^tm1Butl/Mc3r^tm1Butl Tg(Nr5a1-cre)2Lowl/0
Genetic Background	involves: C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc3r^tm1Butl mutation (1 available); any Mc3r mutation (31 available)
Tg(Nr5a1-cre)2Lowl mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased lean body mass ( J:178147 )

• on a standard chow diet

adipose tissue

abnormal adipose tissue amount ( J:178147 )

• increase in fat mass in mice on a standard diet is attenuated compared to homozygous mice not expressing the cre transgene

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:178147 )

N	• unlike in homozygous mice not expressing the cre transgene, hyperinsulinemia, reduced energy expenditure per kg of body weight and reduced respiratory exchange ratio are not seen

abnormal circulating leptin level ( J:178147 )

• hyperleptinemia is partially attenuated compared to homozygous mice not expressing the cre transgene

decreased circulating triglyceride level ( J:178147 )

• lower levels of total triglycerides

abnormal energy homeostasis ( J:178147 )

• under a restricted feeding protocol more food is required to protect mice from weight loss exceeding 15% of initial body weight

behavior/neurological

abnormal locomotor activation ( J:178147 )

• partial rescue of reduced activity compared to homozygous mice not expressing the cre transgene

• food anticipatory activity is attenuated

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