All Phenotypes Heyl<tm1Kkb> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Heyl^tm1Kkb/Heyl^tm1Kkb	Not Specified	MGI:5302519
cx2	Hey1^tm1Kkb/Hey1^tm1Kkb Heyl^tm1Kkb/Heyl^tm1Kkb	B6.Cg-Hey1^tm1Kkb Heyl^tm1Kkb	MGI:5302522
cx3	Hey1^tm1Kkb/Hey1^tm1Kkb Heyl^tm1Kkb/Heyl^tm1Kkb	involves: 129S7/SvEvBrd * C57BL/6	MGI:5302521

Allelic Composition	Heyl^tm1Kkb/Heyl^tm1Kkb
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Heyl^tm1Kkb mutation (1 available); any Heyl mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:178310 )

N	• skeletal muscle weight as a proportion of total body weight is similar to wild-type controls

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:178310 )

• Background Sensitivity: less than 5% of pups on an inbred C57BL/6 (N9) background survive the first 3 weeks of life compared to about 90% of pups on a mixed (N2) background

• survival is better in the N7 generation compared to the F9 generation

muscle

abnormal skeletal muscle satellite cell proliferation ( J:178310 )

• expression analysis indicates satellite cells are not in an undifferentiated quiescent state in adult skeletal muscle in mice from the N7 generation

decreased muscle weight ( J:178310 )

• decrease in muscle weight and muscle weight as a proportion of body weight in mice from the N7 generation compared to littermate controls

abnormal skeletal muscle morphology ( J:178310 )

• satellite cells are slightly larger in mice from the N7 generation compared to littermate controls

decreased skeletal muscle fiber size ( J:178310 )

• in mice from the N7 generation compared to littermate controls

decreased skeletal muscle fiber number ( J:178310 )

• in mice from the N7 generation compared to littermate controls

decreased satellite cell number ( J:178310 )

• in mice from the N7 generation compared to littermate controls

• gradual decrease in satellite cells with age

impaired skeletal muscle regeneration ( J:178310 )

• regeneration following cardiotoxin injection is impaired in mice from the N7 generation

growth/size/body

decreased body size ( J:178310 )

• slight decrease in body size in mice from the N7 generation compared to littermate controls

decreased body weight ( J:178310 )

• significant decrease in body weight in mice from the N7 generation compared to littermate controls

cellular

abnormal skeletal muscle satellite cell proliferation ( J:178310 )

• expression analysis indicates satellite cells are not in an undifferentiated quiescent state in adult skeletal muscle in mice from the N7 generation

Allelic Composition	Hey1^tm1Kkb/Hey1^tm1Kkb Heyl^tm1Kkb/Heyl^tm1Kkb
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey1^tm1Kkb mutation (0 available); any Hey1 mutation (17 available)
Heyl^tm1Kkb mutation (1 available); any Heyl mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:178310 )

• Background Sensitivity: about 90% of pups survive the first 3 weeks of life on a mixed (N2) background compared to less than 5% of pups on an inbred C57BL/6 (N9) background

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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