About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Efnb1tm1.1Jwu
targeted mutation 1.1, Jiangping Wu
MGI:5302529
Summary 2 genotypes


Genotype
MGI:5302532
cn1
Allelic
Composition		 Efnb1tm1.1Jwu/Efnb1tm1.1Jwu
Tg(Lck-cre)I540Jxm/0
Genetic
Background		 B6.Cg-Efnb1tm1.1Jwu Tg(Lck-cre)I540Jxm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1.1Jwu mutation (0 available); any Efnb1 mutation (15 available)
Tg(Lck-cre)I540Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:178148 )
N
• mice exhibit normal lymphoid organ size and histology and thymocyte development




Genotype
MGI:5302540
cn2
Allelic
Composition		 Efnb1tm1.1Jwu/Efnb1tm1.1Jwu
Efnb2tm1.1Jwu/Efnb2tm1.1Jwu
Tg(Lck-cre)I540Jxm/0
Genetic
Background		 B6.Cg-Efnb2tm1.1Jwu Efnb1tm1.1Jwu Tg(Lck-cre)I540Jxm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1.1Jwu mutation (0 available); any Efnb1 mutation (15 available)
Efnb2tm1.1Jwu mutation (0 available); any Efnb2 mutation (29 available)
Tg(Lck-cre)I540Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Decreased thymus and spleen weight and cellularity in Efnb1tm1.1Jwu/Efnb1tm1.1Jwu Efnb2tm1.1Jwu/Efnb2tm1.1Jwu Tg(Lck-cre)I540Jxm/0 mice

immune system
increased thymocyte apoptosis ( J:178148 )
• in all subpopulations
abnormal T cell differentiation ( J:178148 )
• progression from DN3 to DN4 is impaired compared to in wild-type mice
decreased T cell number ( J:178148 )
• in the spleen and lymph nodes
• however, the number of memory and regulatory T cells in the spleen and lymph nodes is normal
decreased CD4-positive, alpha-beta T cell number ( J:178148 )
• in the thymus, spleen, and lymph nodes
decreased CD8-positive, alpha-beta T cell number ( J:178148 )
• in the thymus, spleen, and lymph nodes

cellular
increased thymocyte apoptosis ( J:178148 )
• in all subpopulations

hematopoietic system
increased thymocyte apoptosis ( J:178148 )
• in all subpopulations
abnormal T cell differentiation ( J:178148 )
• progression from DN3 to DN4 is impaired compared to in wild-type mice
abnormal bone marrow cell morphology/development ( J:178148 )
• in transplantation experiments, bone marrow cells exhibit impaired development and expansion and mature T cells in irradiated recipients compared with wild-type cells
decreased T cell number ( J:178148 )
• in the spleen and lymph nodes
• however, the number of memory and regulatory T cells in the spleen and lymph nodes is normal
decreased CD4-positive, alpha-beta T cell number ( J:178148 )
• in the thymus, spleen, and lymph nodes
decreased CD8-positive, alpha-beta T cell number ( J:178148 )
• in the thymus, spleen, and lymph nodes

endocrine/exocrine glands
increased thymocyte apoptosis ( J:178148 )
• in all subpopulations




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory