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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mecp2tm1.1Meg
targeted mutation 1.1, Michael E Greenberg
MGI:5302542
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mecp2tm1.1Meg/Mecp2tm1.1Meg B6.129-Mecp2tm1.1Meg MGI:5302547
ot2
 		Mecp2tm1.1Meg/Y B6.129-Mecp2tm1.1Meg MGI:5302546


Genotype
MGI:5302547
hm1
Allelic
Composition		 Mecp2tm1.1Meg/Mecp2tm1.1Meg
Genetic
Background		 B6.129-Mecp2tm1.1Meg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Meg mutation (0 available); any Mecp2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:178533 )
N
• female mice are fertile




Genotype
MGI:5302546
ot2
Allelic
Composition		 Mecp2tm1.1Meg/Y
Genetic
Background		 B6.129-Mecp2tm1.1Meg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Meg mutation (0 available); any Mecp2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:178533 )
N
• male mice are fertile

behavior/neurological
behavior/neurological phenotype ( J:178533 )
N
• mice exhibit normal anxiety-related and motor behaviors, social approach, and spatial learning and memory
abnormal response to novelty ( J:178533 )
• mice spend equal time investigating a novel objects or mouse as a familiar object or mouse unlike wild-type mice
abnormal response to novel object ( J:178533 )
• mice spend equal time investigating a novel objects as a familiar object unlike wild-type mice

nervous system
abnormal dendrite morphology ( J:178533 )
• cultured cortical neurons exhibit an increase in the average number of dendritic branches and increased dendritic complexity compared with wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory