nervous system
• hippocampal slices transfected with cre exhibit decreased dendritic spine numbers compared with control neurons
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Allele Symbol Allele Name Allele ID |
Ccne1tm3.1Pisc targeted mutation 3.1, Piotr Sicinski MGI:5304324 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• hippocampal slices transfected with cre exhibit decreased dendritic spine numbers compared with control neurons
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice exhibit normal proliferation rates throughout embryonic brain development, numbers of proliferating progenitor cells in the subventricular zone, and numbers of neural stem/progenitor cells
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• adult mice exhibit reduced spine length, width, and estimated spine volume compared with control mice
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• in the CA1 stratum radiatum, neurons exhibit reduced length of postsynaptic densities compared with control neurons
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• spontaneous excitatory postsynaptic current frequency in CA1 pyramidal neurons is reduced compared to in control neurons
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• field excitatory postsynaptic potential amplitude and slope are decreased compared to in control mice
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• mice exhibit impaired performance in a Morris water maze and spatial reversal learning compared with control mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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