Phenotypes associated with this allele

• Allele Symbol: Lim2^Aca47
• Allele Name: ACMaster abnormality 47
• Allele ID: MGI:5304394
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lim2^Aca47/Lim2^Aca47	C57BL/6J-Lim2^Aca47	MGI:5304399
ht2	Lim2^Aca47/Lim2^+	C57BL/6J-Lim2^Aca47	MGI:5304398

Genotype
MGI:5304399

hm1

• Allelic Composition: Lim2^Aca47/Lim2^Aca47
• Genetic Background: C57BL/6J-Lim2^Aca47

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:179533 )

• at 20 weeks of age, lenses are smaller, less stable, and exhibit cataracts in the nuclear region compared with wild-type lenses

abnormal lens fiber morphology ( J:179533 )

• at 10 weeks of age, lens fiber layers in the equatorial outer cortex are less regularly arranged with wave-like structures and partially increased thickness compared with wild-type lens fibers

cataract ( J:179533 )

nuclear cataract ( J:179533 )

• at 20 weeks of age

small lens ( J:179533 )

• at 20 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract		DOID:83	OMIM:601371 OMIM:PS116200	J:179533

Genotype
MGI:5304398

ht2

• Allelic Composition: Lim2^Aca47/Lim2⁺
• Genetic Background: C57BL/6J-Lim2^Aca47

vision/eye

vision/eye phenotype ( J:179533 )

N • at 4 months, mice exhibit normal visual abilities

abnormal lens morphology ( J:179533 )

• lenses exhibit reduced thickness compared with wild-type mice

• lenses are less affected in size and stability compared with homozygous mice

• however, lenses remain transparent

small lens ( J:179533 )

• at 20 weeks of age, not as severe as in homozygous mice

abnormal eye size ( J:179533 )

• reduced axial eye length