Phenotypes associated with this allele

• Allele Symbol: Lbx1^tm1.1Khan
• Allele Name: targeted mutation 1.1, Kazunori Hanaoka
• Allele ID: MGI:5304400
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lbx1^tm1.1Khan/Lbx1^tm1.1Khan	involves: C57BL/6JJcl * C57BL/6NCrlj * CBA/JNCrlj	MGI:5304416
cn2	Lbx1^tm1.1Khan/Lbx1^tm1.1Khan Myf5^tm3(cre)Sor/Myf5^+	involves: 129S4/SvJaeSor * C57BL/6JJcl * C57BL/6NCrlj * CBA/JNCrlj	MGI:5304420
cn3	Lbx1^tm1.1Khan/Lbx1^tm1.1Khan Tg(CAG-cre/Esr1*)5Amc/0	involves: C57BL/6 * CBA	MGI:5304417

Genotype
MGI:5304416

hm1

• Allelic Composition: Lbx1^tm1.1Khan/Lbx1^tm1.1Khan
• Genetic Background: involves: C57BL/6JJcl * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:178868 )

• mice are viable and fertile and do not exhibit any recognizable external abnormalities

Genotype
MGI:5304420

cn2

• Allelic Composition: Lbx1^tm1.1Khan/Lbx1^tm1.1Khan; Myf5^tm3(cre)Sor/Myf5⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6JJcl * C57BL/6NCrlj * CBA/JNCrlj

muscle

abnormal muscle precursor cell migration ( J:178868 )

• impaired

abnormal skeletal muscle morphology ( J:178868 )

• mice exhibit a reduction in limb extensor muscle mass

growth/size/body

decreased body size ( J:178868 )

• somewhat compared with Lbx1^tm1.1Khan homozygotes

cellular

abnormal muscle precursor cell migration ( J:178868 )

• impaired

Genotype
MGI:5304417

cn3

• Allelic Composition: Lbx1^tm1.1Khan/Lbx1^tm1.1Khan; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: C57BL/6 * CBA

muscle

abnormal skeletal muscle morphology ( J:178868 )

• tamoxifen-treated mice lack limb extensor muscles